Results 161 to 170 of about 131,800 (257)

G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation

Advanced Science, EarlyView.
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang, Qingqing Xu, Yuxin Zhang, Fang Liu, Guangchao Sui, Dangdang Li   +5 more
wiley   +1 more source

Practical considerations for handling implants in proton therapy. [PDF]

J Appl Clin Med Phys
Vilches-Freixas G, Taasti VT, Rinaldi I, Unipan M.   +3 more
europepmc   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

An ESTRO-EPTN Delphi consensus on robustness evaluation in proton therapy. [PDF]

Phys Imaging Radiat Oncol
Fracchiolla F, Meijers A, Orlandi E, Korevaar E, Whitfield G, Jensen K, Hoogeman M, Wijsman R, Jouglar E, Weerd EV, Pérez JM, Rinaldi I, Garbacz-Stryszewska M, Cianchetti M, Feijoo MM, Molinelli S, Elstrøm UV, Pica A, Gosling A, Koczur B, Dahlgren CV, Alterio D, Dale E, Farid G, Compter I, Doyen J, Dale JE, Färlin J, Urbanek K, Fjæra LF, Lambrecht M, Ugland M, Tschiche M, Vidal M, Lowe M, Bütof R, Gulliford S, Comi S, Habraken S, Tessonnier T, Sterpin E, Widesott L.   +41 more
europepmc   +1 more source

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Advanced Science, EarlyView.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu, Fan Li, Runan Zhao, Tao Shu, Weihong Min, Bei‐Wei Zhu   +5 more
wiley   +1 more source

Comprehensive comparison of Bioprotect balloon and Barrigel hydrogel rectal spacers in proton therapy for prostate cancer. [PDF]

BMC Urol
Arnold J.
europepmc   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Advancing proton therapy: Dosimetric superiority of proton arc therapy over IMPT in esophageal cancer treatment. [PDF]

J Appl Clin Med Phys
Cong X, Sebastian E, Liu P, Li X, Dolan J, Dalfson R, Soukup M, Lessard E, Deraniyagala RL, Stevens CW, Chen PY, Ding X.   +11 more
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Relative Biological Effectiveness-Clinical Practice at US Proton Therapy Centers. [PDF]

Int J Part Ther
Lühr A, Mohan R, Mahajan A, Shih HA, Paganetti H.   +4 more
europepmc   +1 more source