Results 161 to 170 of about 271,177 (332)

(OA46) Cost-effectiveness of Proton Beam Therapy for Oncologic Management [PDF]

, 2018
Vivek Verma, Mark V. Mishra, Charles B. Simone   +2 more
openalex   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Radiobiological and Clinical Advantages of Proton Therapy in Modern Cancer Treatment. [PDF]

Cancers (Basel)
Kalospyros SA, Gkikoudi A, Koutsostathis A, Adamopoulou A, Vasilopoulos SN, Rangos V, Stylianou-Markidou E, Pantalos I, Koumenis C, Georgakilas AG.   +9 more
europepmc   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Proton therapy utilization for glioblastoma at a large multicenter academic practice

David J. Crompton, Shelby Kern, Sujay A. Vora, Alfredo Quiñones‐Hinojosa, Terry C. Burns, Wendy Sherman, Paul D. Brown, Nadia Laack, Jennifer Peterson, Joon H. Uhm, Michael W. Ruff, Uğur Sener, William G. Breen, Daniel M. Trifiletti   +13 more
openalex   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Geometry-based framework for beam angle selection in proton therapy for lung cancer. [PDF]

Phys Imaging Radiat Oncol
Fotiou K, Lønne PI, Malinen E.
europepmc   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Norwegian consensus guidelines for selection of neuro-oncology patients to proton therapy. [PDF]

Clin Transl Radiat Oncol
Heggebø LC, Johannessen TA, Magelssen H, Sprauten M, Blakstad H, Brekke J, Goplen D, Marienhagen K, Solheim TS, Bjorland L, Brandal P.   +10 more
europepmc   +1 more source

Efficacy of Triple Therapy with Proton Pump Inhibitor, Levofloxacin and Amoxicillin as First Line Treatment to Eradicate Helicobacter Pylori: An Observational Study

Mohammad Asadur Rahman, Mahedi Hasan, ABM Safiullah, Mohammad Shoaib Chowdhury, Mohammad Syedul Islam, Ahmad Monjurul Aziz, Rana Jahangir Alam, Khalada Binte Khair   +7 more
openalex   +1 more source