Results 171 to 180 of about 138,042 (257)

Radiobiological and Clinical Advantages of Proton Therapy in Modern Cancer Treatment. [PDF]

Cancers (Basel)
Kalospyros SA, Gkikoudi A, Koutsostathis A, Adamopoulou A, Vasilopoulos SN, Rangos V, Stylianou-Markidou E, Pantalos I, Koumenis C, Georgakilas AG.   +9 more
europepmc   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Proton Therapy for Head and Neck Adenoid Cystic Carcinoma: A Multi-institutional Review. [PDF]

Int J Part Ther
McGee LA, Rohit A, Buras M, Bajaj G, Chang JH, Kalman NS, Grover R, Akthar A, Kole AJ, McDonald M, Katz S, Lee N, Tsai H, Urbanic J, Vargas C, Zeng J, Molitoris J, Lester S, Mohammadi H, Holtzman A.   +19 more
europepmc   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Retrospective analysis of adaptation frequencies and factors in offline in offline adaptive proton therapy. [PDF]

J Appl Clin Med Phys
Pak F, Zhang H, Hao Y, Schmidt M, Liu W, Schiff J, Laugeman E, Watts M, Perkins S, Zhao T.   +9 more
europepmc   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Postoperative proton therapy in uterine and cervical cancer: promising evidence but remaining questions. [PDF]

Transl Cancer Res
Wessel L, Arians N.
europepmc   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

Outcomes of Salvage Proton Therapy After Primary Cryosurgery or High-Intensity Focused Ultrasound for Recurrent Localized Prostate Cancer. [PDF]

Int J Part Ther
Lichlyter DA, Mendenhall NP, Fortna M, Mendenhall WM, Charles Nichols R, Bryant CM.   +5 more
europepmc   +1 more source