Results 121 to 130 of about 147,513 (305)

Dosimetric comparison of gantry and horizontal fixed‐beam proton therapy treatment plans for base of skull chordoma

Journal of Medical Radiation Sciences
Introduction Australia's first proton beam therapy (PBT) centre will house a fixed‐beam room and two gantry rooms. As the only PBT facility in Australia for at least the short term, there is a need to efficiently allocate treatment appointments between ...
Emma Shierlaw, Melanie Penfold, Rosanna Crain, Alexandre M.C. Santos, Scott N. Penfold   +4 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Improving proton therapy by metal-containing nanoparticles: nanoscale insights

, 2016
Thomas Schlathölter,1 Pierre Eustache,2 Erika Porcel,2 Daniela Salado,2 Lenka Stefancikova,2 Olivier Tillement,3 Francois Lux,3 Pierre Mowat,3 Aleksandra K Biegun,4 Marc-Jan van Goethem,4 Hynd Remita,5 Sandrine Lacombe2 1Zernike Institute for ...
Porcel E, Lux F, Lacombe S, Biegun AK, Stefancikova L, Eustache P, Remita H, van Goethem MJ, Schlathölter T, Mowat P, Salado D, Tillement O   +11 more
core  

Influence of Geant4 parameters on proton dose distribution

, 2015
Purpose: The proton therapy presents a great precision during the radiation dose delivery. It is useful when the tumor is located in a sensitive area like brain or eyes. The Monte Carlo (MC) simulations are usually used in treatment planning system (TPS)
Merouani, Asad; Department of Physics, Faculty of Science, Mohammed V University, Rabat, El-Khayati, Naima; Department of Physics, Faculty of Science, Mohammed V University, Rabat, Amoros, Gabriel; Instituto de Física Corpuscular, Consejo Superior de Investigaciones Cientificas (CSIC/UV), Valencia   +2 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

PAMELA overiew and status

, 2010
The status of PAMELA (Particle Accelerator for MEdical Applications) – an accelerator for proton and light ion therapy using a non-scaling FFAG (ns-FFAG) accelerator – is reviewed and ...
Easton, M.J., Tzenov, S.I., Khan, A., McIntosh, P.A., Witte, H., Johnstone, C., Bliss, N., Machida, S., Edgecock, R., Kelliher, D.J., Jones, T.J., Cobb, J H, Pozinski, J., Pasternak, J, Peach, K. J., Owen, H.L., Pattalwar, S.M., Fenning, R.J.L., Vojnovic, B., Barlow, Roger, Aslaninejad, M., Jones, B., Yokoi, T., Sheehy, S.L., Tygier, S.C., Gardner, I.S.K., Beard, C.D., Hill, M.A., Seviour, Rebecca, Strachan, J., Smith, S.L.   +30 more
core  

NRG Oncology Liver Proton SBRT and Hypofractionated Radiation Therapy: Current Treatment Technical Assessment and Practice Patterns

Background/Objectives: Proton therapy delivers highly conformal doses to the target area without producing an exit dose, minimizing cumulative doses to healthy liver tissue. This study aims to evaluate current practices, challenges, and variations in the
Theodore S. Hong, Jun Zhou, Charles B. Simone, Saini, Jatinder, Zhou, Jun, Xiao, Ying, Simone, Charles B, Liu, Wei, Shen, Jiajian, Lin, Liyong, Jatinder Saini, Liyong Lin, Minglei Kang, Kang, Minglei, Hong, Theodore S, Paige A. Taylor, Ying Xiao, Jiajian Shen, Kristin Higgins, Wei Liu, Higgins, Kristin, Taylor, Paige A   +21 more
core   +1 more source

Generation of quasi-monoenergetic protons from thin multi-ion foils by a combination of laser radiation pressure acceleration and shielded Coulomb repulsion

, 2013
We study theoretically and numerically the acceleration of protons by a combination of laser radiation pressure acceleration and Coulomb repulsion of carbon ions in a multi-ion thin foil made of carbon and hydrogen.
He, Minqing, Wang, Jyhpung, Liu, Tung-Chang, Shao, Xi, Chen, Shih-Hung, Liu, Chuan-Sheng, Su, Jao-Jang, Eliasson, Bengt, Tripathi, Vipin   +8 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Optimization of electrode position in electric field treatment for pancreatic cancer

BMC Gastroenterology
Background In electric field-based cancer treatment, the intensity of the electric field applied to the tumor depends on the position of the electrode array, directly affecting the efficacy of treatment.
Sangcheol Kim, Yousun Ko, Dongho Shin, Haksoo Kim, Sung Uk Lee, Jonghyun Kim, Tae Hyun Kim, Myonggeun Yoon   +7 more
doaj   +1 more source