Results 101 to 110 of about 5,053,091 (357)

A Comparison Study of Machine Learning (Random Survival Forest) and Classic Statistic (Cox Proportional Hazards) for Predicting Progression in High-Grade Glioma after Proton and Carbon Ion Radiotherapy

Frontiers in Oncology, 2020
BackgroundMachine learning (ML) algorithms are increasingly explored in glioma prognostication. Random survival forest (RSF) is a common ML approach in analyzing time-to-event survival data.
Xianxin Qiu, Xianxin Qiu, Jing Gao, Jing Gao, Jing Yang, Jing Yang, Jiyi Hu, Jiyi Hu, Weixu Hu, Weixu Hu, Lin Kong, Lin Kong, Jiade J. Lu, Jiade J. Lu   +13 more
doaj   +1 more source

Current status of proton therapy techniques for lung cancer

Radiation Oncology Journal, 2019
Proton beams have been used for cancer treatment for more than 28 years, and several technological advancements have been made to achieve improved clinical outcomes by delivering more accurate and conformal doses to the target cancer cells while ...
Youngyih Han
semanticscholar   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Respiratory-gated proton beam therapy for intrahepatic cholangiocarcinoma without fiducial markers

Radiation Oncology
Background Intrahepatic cholangiocarcinoma (ICC) is a challenging primary liver cancer with a poor prognosis, especially in unresectable cases. Traditional palliative irradiation is limited in reducing liver doses.
Akihito Okubo, Sae Matsumoto, Hiroyasu Tamamura, Yoshitaka Sato, Satoko Asahi, Hitoshi Tatebe, Kazutaka Yamamoto, Keiichiro Matsushita, Makoto Sasaki, Yoshikazu Maeda, Yuji Tameshige, Hajime Sunagozaka, Hiroyuki Aoyagi, Satoshi Shibata, Shigeyuki Takamatsu, Satoshi Kobayashi   +15 more
doaj   +1 more source

Magnetically Guided Mechanoactive Mineralization Scaffolds for Enhanced Bone Regeneration

Advanced Functional Materials, EarlyView.
A 3D‐printed ‘rebar‐concrete’ inspired scaffold (PGS‐P@MGel) synergizes spontaneous biomineralization with magneto‐mechanical stimulation through PDA@Fe3O4‐embedded hydrogel. This dual biointerface activates Piezo1/β‐catenin/YAP mechanotransduction axis, enhancing BMSCs osteogenesis and angiogenesis simultaneously.
Xuran Guo, Zaijin Tao, Zhenzhen Dai, Yinghua Gao, Chengzhen Chu, Cunyi Fan, Shen Liu, Xin Ma, Fangchun Jin, Zhengwei You, Jia Jiang   +10 more
wiley   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Possible association of dose rate and the development of late visual toxicity for patients with intracranial tumours treated with pencil beam scanned proton therapy

Radiation Oncology
Background and purpose Rare but severe toxicities of the optic apparatus have been observed after treatment of intracranial tumours with proton therapy.
Arturs Meijers, Juliane Daartz, Antje-Christin Knopf, Michelle van Heerden, Nicola Bizzocchi, Miriam Varela Vazquez, Barbara Bachtiary, Alessia Pica, Helen A Shih, Damien Charles Weber   +9 more
doaj   +1 more source

Dosimetric accuracy and radiobiological implications of ion computed tomography for proton therapy treatment planning

Physics in Medicine and Biology, 2019
Ion computed tomography (iCT) represents a potential replacement for x-ray CT (xCT) in ion therapy treatment planning to reduce range uncertainties, inherent in the semi-empirical conversion of xCT information into relative stopping power (RSP).
S. Meyer, F. Kamp, T. Tessonnier, A. Mairani, C. Belka, D. Carlson, C. Gianoli, K. Parodi   +7 more
semanticscholar   +1 more source

Supervariate Gel Transforms into Various Biominerals in Salt Solutions

Advanced Functional Materials, EarlyView.
It is revealed that common calcium‐based biominerals can form from a stable, non‐toxic ‘supervariate’ gel. This tunable gel selectively yields calcite or hydroxyapatite in carbonate/phosphate solutions, while CaCl₂ facilitates the formation of dihydrate calcium pyrophosphate, which converts to hydroxyapatite upon drying. These findings provide insights
Xinxue Tang, Chong Wang, Yuk‐Tong Cheng, Junda Shen, Yunchen Long, Hongkun Li, Jie Yan, Yang Ren, Xiao Ma, Yufeng Huang, Zhengtao Xu, Jian Lu, Yang Yang Li   +12 more
wiley   +1 more source

Predicting late magnetic resonance image changes in glioma patients after proton therapy

Acta oncologica, 2019
Proton beam therapy (PBT) is expected to reduce radiation-induced side-effects compared to state-of-the-art photon treatments as the physical properties of protons offer the possibility to spare no...
J. Eulitz, E. Troost, F. Raschke, E. Schulz, B. Lutz, Almut Dutz, Steffen Löck, Patrick Wohlfahrt, Wolfgang Enghardt, C. Karpowitz, Mechthild Krause, A. Lühr   +11 more
semanticscholar   +1 more source