Results 161 to 170 of about 249,684 (338)

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Preliminary clinical report of proton therapy at hyogo ion beam medical center (HIBMC) [PDF]

, 2002
Masao Murakami, K. Kagawa, Yoshio Hishikawa, Manabu Abe, Sadao Kamidono, Noriaki Tsubota, Norio Nakao, Kiyoshi Yoshino   +7 more
openalex   +1 more source

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Modeling and Validation of a Proton Therapy Couch Top. [PDF]

Int J Part Ther
Batin E, Faught A, Lee H, Ayan A.
europepmc   +1 more source

Referring Patients Abroad for Proton Therapy

, 2000
Emily Wilson
openalex   +1 more source

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

Bridging the proton gap: A proton therapy consultation service for Canadian radiation oncologists. [PDF]

Tech Innov Patient Support Radiat Oncol
Kim I, Parent A, Holwell M, Craig T, Lindsay P, Le H, Tsang Y, Johnson PB, Indelicato DJ, Liu FF, Tsang DS.   +10 more
europepmc   +1 more source

Eye-preserving proton radiation therapy (PRT) for medium and large choroidal melanoma

, 2000
M. Fuß, Lilia Loredo, Roger Grove, J. Slater   +3 more
openalex   +1 more source

A non-resonant RF cavity loaded with amorphous alloy for proton cancer therapy [PDF]

, 2003
Yoshimasa Makita, Hiroshi Harada, T. Nayayama, H. Tsuchidate, C. Tsukishima, Kyoko Yoshida   +5 more
openalex   +1 more source

Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology

Advanced Science, EarlyView.
This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou, Yuwei Wang, Yu Liu, Feipeng Zhu, Ge Gao, Chengjie Li, Pu Ai, Jingying Xu, Junxin Wang, Long Guo, Yuting Guan, Virginia Man‐Yee Lee, Jianjun Chen, Jialin Zheng, Qihui Wu   +14 more
wiley   +1 more source