BMC Oral Health, 2020 Background The primary aim of this study was to observe the effect of 5-ALA-mediated photodynamic therapy on oral squamous cell carcinoma in vitro. Methods SCC25 cells were divided into the observation group and the blank control group.
Ying Ma +4 more
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Protoporphyrin IX photodynamic therapy for synovitis [PDF]
Arthritis & Rheumatism, 2002 AbstractObjectiveTo determine the conditions for synovial accumulation of protoporphyrin IX (PpIX) and photodynamic therapy (PDT)–induced synovial cytotoxicity in vitro and in vivo.MethodsSynovial tissues were obtained from mice with antigen‐induced arthritis (AIA) and incubated with different concentrations of 5‐aminolevulinic acid hexyl ester (h‐ALA),
Kirdaite, G. +5 more
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Molecular Dynamics of Cobalt Protoporphyrin Antagonism of the Cancer Suppressor REV-ERBβ
Molecules, 2021 Nuclear receptor REV-ERBβ is an overexpressed oncoprotein that has been used as a target for cancer treatment. The metal-complex nature of its ligand, iron protoporphyrin IX (Heme), enables the REV-ERBβ to be used for multiple therapeutic modalities as a
Taufik Muhammad Fakih +4 more
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Fluorescence‐based discrimination of breast cancer cells by direct exposure to 5‐aminolevulinic acid
Cancer Medicine, 2019 Protoporphyrin IX‐fluorescence measurement is a powerful in situ approach for cancer detection after oral/topical administration of 5‐aminolevulinic acid.
Midori Morita +8 more
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Synthesis of Two Compounds with Self-Assembled Monolayer Properties: Riboflavin 2', 3', 4' , 5' Tetra Octadecanoate & Bis (Phosphatidyl Ethanol) Protoporphyrin IX Amide [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2011 Riboflavin and protoporphyrin IX are two molecules that participate in oxidation and reduction reactions in the living cell. Changing some functional groups of riboflavin and protoporphyrin IX can provide compounds with self-assembled monolayer ...
Mohammad Mirzaei Salehabady +4 more
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Antimicrobial Photodynamic Therapy in the Control of COVID-19
Antibiotics, 2020 Antimicrobial photodynamic therapy (aPDT), using well known, safe and cost-effective photosensitizers, such as phenothiazines, e.g., methylene blue (MB), or porphyrins, e.g., protoporphyrin-IX (PP-IX), might help to mitigate the COVID-19 either to ...
Adelaide Almeida +2 more
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Protoporphyrin IX: the Good, the Bad, and the Ugly [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2016 Protoporphyrin IX (PPIX) is ubiquitously present in all living cells in small amounts as a precursor of heme. PPIX has some biologic functions of its own, and PPIX-based strategies have been used for cancer diagnosis and treatment (the good). PPIX serves as the substrate for ferrochelatase, the final enzyme in heme biosynthesis, and its homeostasis is ...
Madhav, Sachar +2 more
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Inactivation of Dengue and Yellow Fever viruses by heme, cobalt-protoporphyrin IX and tin-protoporphyrin IX [PDF]
Journal of Applied Microbiology, 2016 To investigate the effect of heme, cobalt-protoporphyrin IX and tin-protoporphyrin IX (CoPPIX and SnPPIX), macrocyclic structures composed by a tetrapyrrole ring with a central metallic ion, on Dengue Virus (DENV) and Yellow Fever Virus (YFV) infection.Treatment of HepG2 cells with heme, CoPPIX and SnPPIX after DENV infection reduced infectious ...
I, Assunção-Miranda +8 more
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Butafenacil: A positive control for identifying anemia- and variegate porphyria-inducing chemicals
Toxicology Reports, 2015 Butafenacil is an herbicide that inhibits protoporphyrinogen oxidase (PPOX), an enzyme that catalyzes oxidation of protoporphyrinogen IX to protoporphyrin IX during chlorophyll and heme biosynthesis.
Jessica K. Leet +2 more
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Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target. [PDF]
PLoS ONE, 2009 Heme (Fe2+ protoporphyrin IX) is an essential molecule that has been implicated the potent antimalarial action of artemisinin and its derivatives, although the source and nature of the heme remain controversial.
Shiming Zhang, Glenn S Gerhard
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