Results 31 to 40 of about 13,793 (186)
Butafenacil: A positive control for identifying anemia- and variegate porphyria-inducing chemicals
Toxicology Reports, 2015 Butafenacil is an herbicide that inhibits protoporphyrinogen oxidase (PPOX), an enzyme that catalyzes oxidation of protoporphyrinogen IX to protoporphyrin IX during chlorophyll and heme biosynthesis.
Jessica K. Leet +2 more
doaj +1 more source
Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target. [PDF]
PLoS ONE, 2009 Heme (Fe2+ protoporphyrin IX) is an essential molecule that has been implicated the potent antimalarial action of artemisinin and its derivatives, although the source and nature of the heme remain controversial.
Shiming Zhang, Glenn S Gerhard
doaj +1 more source
Thermoelectric Properties of Composite Nanoparticle Array with Protoporphyrin Molecule Junctions
MATEC Web of Conferences, 2017 Composite nano-structures have many interesting properties and potential applications. For a molecule-nanoparticle (NP) composite array, its properties may strongly depend on the molecules on/between NPs. For instance, the resistance of NP composite film
Ni l-Chih, Tzeng Shien-Der
doaj +1 more source
Frontiers in Plant Science, 2017 Magnesium protoporphyrin IX methyltransferase (ChlM) catalyzes the formation of magnesium protoporphyrin IX monomethylester (MgPME) from magnesium protoporphyrin IX (MgP) in the chlorophyll synthesis pathway. However, no ChlM gene has yet been identified
Zhaohai Wang +11 more
doaj +1 more source
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria
Nature CommunicationsErythropoietic protoporphyria (EPP) is a genetic disease characterized by protoporphyrin IX-mediated painful phototoxicity. Currently, options for the management of EPP-associated phototoxicity are limited and no oral medication is available.
Junjie Zhu +8 more
doaj +1 more source
Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source
Antioxidants, 2022 An important virulence trait of Salmonella enterica serovar Typhimurium (S. Typhimurium) is the ability to avoid the host immune response, generating systemic and persistent infections.
Valentina P. Sebastián +13 more
doaj +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
The Journal of Pathology, EarlyView.Abstract Ductular reactions (DRs) are dynamic and complex multicellular responses that occur as a result of various hepatic injuries. Precise identification and quantification of the extent of DRs is a cornerstone of pre‐clinical modelling of liver disease, with links to inflammation, fibrosis, regeneration, and disease severity.
Nathalie Feeley +15 more
wiley +1 more source