Relationship between blood Lead status and anemia in Ugandan children with malaria infection
BMC Pediatrics, 2020 Background In Uganda, childhood anemia remains a health challenge and is associated with malaria infection as well as iron deficiency. Iron deficiency is intertwined with nutritional status, age and other comorbidities including helminths and Lead ...
Ambrose Mukisa +4 more
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Zinc protoporphyrin binding to telomerase complexes and inhibition of telomerase activity*
Pharmacology Research & Perspectives, 2021 Zinc protoporphyrin (ZnPP), a naturally occurring metalloprotoporphyrin (MPP), is currently under development as a chemotherapeutic agent although its mechanism is unclear.
Zhaowen Zhu +8 more
doaj +1 more source
Eggshell spottiness reflects maternally transferred antibodies in blue tits. [PDF]
PLoS ONE, 2012 Blue-green and brown-spotted eggshells in birds have been proposed as sexual signals of female physiological condition and egg quality, reflecting maternal investment in the egg. Testing this hypothesis requires linking eggshell coloration to egg content,
Marie-Jeanne Holveck +6 more
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Formation of meso, N-diphenylprotoporphyrin IX by an aerobic reaction of phenylhydrazine with oxyhemoglobins. [PDF]
, 2003 Administration of phenylhydrazine to rabbits resulted in the denaturation of hemoglobins in erythrocytes, causing the formation of intracellular precipitates known as Heinz bodies, severe hemolytic anemia, and reticulocytosis.
Abe, Tadashi +8 more
core +1 more source
Metalloporphyrins inactivate caspase-3 and -8 [PDF]
, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B. +8 more
core +1 more source
Anaemia, iron deficiency and vitamin A status among school-aged children in rural Kazakhstan. [PDF]
, 2005 OBJECTIVES: To investigate the prevalence of anaemia and iron deficiency and vitamin A status among school-aged children in rural Kazakhstan and identify factors associated with anaemia in this population. DESIGN: A cross-sectional design.
Alnazarova, Akmaral +9 more
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A novel high-content immunofluorescence assay as a tool to identify at the single cell level γ-globin inducing compounds [PDF]
, 2015 The identification of drugs capable of reactivating γ-globin to ameliorate β-thalassemia and Sickle Cell anemia is still a challenge, as available γ-globin inducers still have limited clinical indications.
Antonella Ronchi +14 more
core +7 more sources
PLoS ONE, 2015 We previously identified heme oxygenase 1 (HO-1) as a specific target of miR-155, and inhibition of HO-1 activity restored the capacity of miR-155-/- CD4+ T cells to promote antigen-driven inflammation after adoptive transfer in antigen-expressing ...
Jinyu Zhang, Michel Y Braun
doaj +1 more source
Heme oxygenase 1 is differentially involved in blood flow-dependent arterial remodeling: role of inflammation, oxidative stress, and nitric oxide [PDF]
, 2011 Heme oxygenase 1 is induced by hemodynamic forces in vascular smooth muscle and endothelial cells. We investigated the involvement of heme oxygenase 1 in flow (shear stress)-dependent remodeling.
A. Caillon +7 more
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Prolonged Allogeneic Islet Graft Survival by Protoporphyrins
Cell Transplantation, 2005 Transplantation of islets of Langerhans in patients with type 1 diabetes allows for improved metabolic control and insulin independence. The need for chronic immunosuppression limits this procedure to selected patients with brittle diabetes.
Antonello Pileggi +9 more
doaj +1 more source