Results 51 to 60 of about 217,132 (268)

Perancangan User Interface dan User Experience Aplikasi Klinik Gigi Menggunakan Metode Design Thinking

open access: yesJurnal Saintekom
Klinik Gigi drg. Ema Medika so far still provides services to patients manually and keeps medical records using paper documents. This causes data invalidity and sometimes the confidentiality of patient data cannot be maintained properly.
Dhea Putri Salsabila   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

MODELING, DYNAMIC AND THERMAL ANALYSIS OF THE PROTOTYPE MAGNETORHEOLOGICAL CLUTCH [PDF]

open access: yesScientific Journal of Silesian University of Technology. Series Transport, 2014
This paper presents the complex results concerning the prototype clutch with magnetorheological (MR) fluid. The obtained characteristics depicts the dependencies between the clutch’s torque and: the intensity of the magnetic field induced by the coil ...
Jerzy BAJKOWSKI
doaj  

NewRadial: Challenging scales and standards of humanities scholarship through new knowledge environment prototypes

open access: yesDigital Studies, 2015
Even though large aggregations of humanities data are emerging through the efforts of significant federations, the larger the collection, the more difficult it is for large-scale standards to effectively account for and relate the complex variety of data
Jon Saklofske, Jon Saklofske
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MOTION STUDY OF A WHEELCHAIR PROTOTYPE FOR DISABLED PEOPLE [PDF]

open access: yesFiabilitate şi Durabilitate, 2015
In this paper is presented the design and experimental prototype of a wheelchair for disabled people. Design solution proposed to be implemented uses two reduction gears motors and a mechanical transmission with chains.
Ionut GEONEA, Nicolae DUMITRU
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Prototype Alat Pengendali Lampu dengan Perintah Suara menggunakan Arduino Uno Berbasis Web

open access: yesJurnal RESTI (Rekayasa Sistem dan Teknologi Informasi), 2019
The use of electric power for lights often less considered, a lot of lights are on continuously even though it's not used. As a result, a lot of electricity is wasted.
Nurul Isna Ganggalia   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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