Results 71 to 80 of about 1,432,245 (303)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Jurnal SaintekomKlinik Gigi drg. Ema Medika so far still provides services to patients manually and keeps medical records using paper documents. This causes data invalidity and sometimes the confidentiality of patient data cannot be maintained properly.
Dhea Putri Salsabila +2 more
doaj +1 more source
Jurnal Ilmiah Ilmu Administrasi Publik, 2020 This study aims to develop a Human Resources competency strategy at the Barru Regent's Office. This research specifically focuses on the prototype design of Human Resources Development apparatus strategies that are effectively used by the Barru district ...
Andi Rahmatiah Rasyid
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
MODELING, DYNAMIC AND THERMAL ANALYSIS OF THE PROTOTYPE MAGNETORHEOLOGICAL CLUTCH [PDF]
Scientific Journal of Silesian University of Technology. Series Transport, 2014 This paper presents the complex results concerning the prototype clutch with magnetorheological (MR) fluid. The obtained characteristics depicts the dependencies between the clutch’s torque and: the intensity of the magnetic field induced by the coil ...
Jerzy BAJKOWSKI
doaj
Digital Studies, 2015 Even though large aggregations of humanities data are emerging through the efforts of significant federations, the larger the collection, the more difficult it is for large-scale standards to effectively account for and relate the complex variety of data
Jon Saklofske, Jon Saklofske
doaj +1 more source
Prototype resupply scheduler [PDF]
Resupply scheduling for the Space Station presents some formidable logistics problems. One of the most basic problems is assigning supplies to a series of shuttle resupply missions.
Byrd, Jim, Hughes, Angi, Tanner, Steve
core +1 more source
The AEI 10 m prototype interferometer [PDF]
, 2010 A 10 m prototype interferometer facility is currently being set up at the AEI in Hannover, Germany. The prototype interferometer will be housed inside a 100 m^3 ultra-high vacuum envelope. Seismically isolated optical tables inside the vacuum system will
Chen, Yanbei, Goßler, S., Somiya, K.
core