Results 101 to 110 of about 610,579 (177)

Exploration of Moringa Oleifera and Curcuma Longa Compounds as Multi-Target Agents for Alzheimer’s Disease Through Bioinformatics Analysis

Scripta Score Scientific Medical Journal
Background: Alzheimer’s disease is a multifactorial neurodegenerative disorder. Current synthetic inhibitors often fail to address its complexity. Natural multitarget agents like Moringa oleifera and Curcuma longa may offer safer alternatives. Objective:
Shakira, Meutia Maulina
doaj   +1 more source

Identification of novel molecular scaffolds for the design of MMP-13 inhibitors through Virtual Screening Methods [PDF]

, 2010
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients. It is characterized by progressive loss of articular cartilage that eventually leads to denudation of the joint surface.
La Pietra, Valeria
core   +1 more source

Molecular docking, prediction of drug-likeness properties, and toxicity risk assessment of compounds from Cinnamomum zeylanicum as inhibitors of Dengue DEN2 NS2B/NS3.

Chempublish Journal
Dengue hemorrhagic fever (DHF) is a serious mosquito-borne disease caused by the dengue virus, most often transmitted by the bite of female Aedes aegypti mosquitoes.
Neni Frimayanti, Armon Fernando, Rizka I’zaa Rahmah, Benni Iskandar   +3 more
doaj   +1 more source

Pharmacology of Proteasome inhibitors

, 2020
A review on the pharmacology of proteasome inhibitors. It focuses on its pharmacokinetics and its pharmacodynamics, mechanism of action and its effect on the therapy of various cancers especially in multiple myeloma and solid tumors.általános ...
Omalu, Chinedu Stephen
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Exploring benzimidazole derivatives as potential inhibitors of chikungunya virus protease using in silico methods

Discover Chemistry
Chikungunya virus poses a significant public health risk due to the absence of specific antiviral treatments. It causes serious symptoms, such as polyarthralgia, high fever, muscle pain, nausea, and rash.
Jeffrey E. Sampson, Chandan Nakum, Joseph Muganga, Julius Mashaga   +3 more
doaj   +1 more source

Repurposing of Food and Drug Admnistration (FDA) approved library to identify a potential inhibitor of trypanothione synthetase for developing an antileishmanial agent

Heliyon
Leishmaniasis is one of the top 10 neglected tropical diseases. Globally, it impacts more than 12 million individuals. In light of the absence of a safer, affordable treatment for the Leishmaniasis, along with therapeutic failures and drug resistance ...
Divya Vemula, Shreelekha Mohanty, Vasundhra Bhandari   +2 more
doaj   +1 more source

Molecular mechanisms underlying the erectogenic effects of nutraceutical lunamarine, a novel PDE5 inhibitor derived from watermelon (Citrullus lanatus)

Discover Food
The research paper investigates the phytochemicals of watermelon (Citrullus lanatus) as potential novel inhibitors of phosphodiesterase type 5 (PDE5), which is essential for treating erectile dysfunction and pulmonary arterial hypertension.
Oluwaseun E. Agboola, Zainab A. Ayinla, Samuel S. Agboola, Theophilus A. Adegbuyi, Janet F. Akinseye, A. Sijuade, Adebimpe H. Egbebi, Olutosin S. Ilesanmi, Adebanke A. Agboola, Oluwatobi K. Ibrahim   +9 more
doaj   +1 more source

Computational analysis and molecular dynamics simulation of metformin derivatives as potential α-glucosidase inhibitors for type 2 diabetes

Results in Chemistry
Type 2 Diabetes Mellitus (T2DM) is a progressive metabolic disorder that necessitates safer and more effective therapeutic strategies. Inhibition of α-glucosidase plays a crucial role in reducing postprandial hyperglycemia.
Nor Akmalyati Sulong, Hisashi Okumura, Satoru G. Itoh, Chin Fei Chee, Mohd Rafie Johan, Vannajan Sanghiran Lee   +5 more
doaj   +1 more source

Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1

2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds.
Blackman, M. J., Penzo, M., Fulle, S., Ebejer, J. P., Jirgensons, Aigars, Finn, P. W., Kher, Samir Satish   +6 more
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Avaliação de biótipos de leiteiro com suspeita de resistência a herbicidas inibidores da ALS e Protox [PDF]

, 2014
The objective of the present study was to evaluate the confirmation of occurrence of wild poinsettia resistance, coming from Rondônia and Rio Grande do Sul, to herbicides with different mechanisms of action, and to determine the dose of herbicides ...
Kujawiski, Renato, Radünz, André Luiz, Perin, Gismael Francisco, Trevisol, Ricardo, Prigol, Alana, Galon, Leandro, Trezzi, Michelangelo Muzell, Forte, César Tiago, Concenço, Germani   +8 more
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