Results 51 to 60 of about 610,579 (177)

Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]

, 2013
Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Gucký, Tomáš, Stefan Zahler, Krystof, Vladimir, Strnad, Miroslav, Liebl, Johanna, Vollmar, Angelika M., Fürst, Robert, Vladimir Krystof, Robert Fürst, Sabine B Weitensteiner, Miroslav Strnad, Johanna Liebl, Havlíček, Libor, Tomáš Gucký, Weitensteiner, Sabine B., Zahler, Stefan, Libor Havlíček, Angelika M Vollmar   +17 more
core   +2 more sources

Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis

BMC Complementary Medicine and Therapies, 2021
Background Hypercholesterolemia has posed a serious threat of heart diseases and stroke worldwide. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid biosynthesis, is regarded as the root of reactive oxygen species (ROS) that generate ...
Rishab Marahatha, Saroj Basnet, Bibek Raj Bhattarai, Prakriti Budhathoki, Babita Aryal, Bikash Adhikari, Ganesh Lamichhane, Darbin Kumar Poudel, Niranjan Parajuli   +8 more
doaj   +1 more source

Exploring the Anticancer Potential of Novel Piperidine‐Embedded Isoxazol–Triazole Conjugates Against MCF‐7 Human Breast Adenocarcinoma Cell Line: Design, Synthesis, In Silico, and In Vitro Investigations

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Novel piperidine–embedded isoxazol–triazole conjugates (6a‐6o) were designed, synthesized, and evaluated for anticancer activity against MCF‐7 breast cancer cells, with selectivity assessed using noncancerous HEK293 cells. Compound 6m showed the most potent antiproliferative activity (GI50 < 10 µg/mL; SI > 5), comparable to doxorubicin, highlighting ...
Jay R. Ghonia, Jigisha Parikh, Bharatkumar Z. Dholakiya   +2 more
wiley   +1 more source

Discovery and validation of SIRT2 inhibitors based on tenovin-6 : use of a 1H-NMR method to assess deacetylase activity [PDF]

, 2012
The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Pirrie, L, Sonia Lain, Major, LL, Zubriene, Asta, Lebl, T, Matulis, Daumantas, Lisa Pirrie, Morkunaite, Vaida, Tomas Lebl, McCarthy, Anna R., Asta Zubrienė, Louise L. Major, Matulis, D, Lain, Sonia, Daumantas Matulis, Morkunaite, V, Nicholas J. Westwood, Vaida Morkūnaitė, Major, Louise L., Westwood, NJ, Anna R. McCarthy, McCarthy, AR, Zubriene, A, Lebl, Tomas, Lain, S, Westwood, Nicholas J., Pirrie, Lisa   +26 more
core   +1 more source

Role of Selective Cyclooxygenase-2 Inhibitors in Renal Colic Pain Reduction and Improvement: A Systematic Review of Clinical Trials [PDF]

, 2023
Renal colic is an irritating condition that develops after obstruction of the ureter. Selective cyclooxygenase-2 inhibitors are types of non-steroidal anti-inflammatory drugs (NSAIDs) that have beneficial role in treatment various diseases.
Mohammadian Amiri, Mehdi, Darvishi, Mohammad, Demin Al-Khafaji, Ali Hussein, Abosaooda, Munther, Emadichashmi, Sepidehalsadat, Hameed Fayyadh, Shaimaa, Romero Parra, Rosario Mireya   +6 more
core   +1 more source

Exploring the Multitarget Pharmacological Potential of Halogeton sativus Secondary Metabolites: An Integrated Experimental and Computational Approach

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Halogeton sativus is investigated through phytochemical isolation, biological evaluation, molecular dicking, molecular dynamics simulation, and ADMET prediction. The identified metabolites exhibit promising antioxidant, anti‐inflammatory, antimicrobial, and antidiabetic activities, while computational analyses provide mechanistic insights and favorable
Abd Elbasset Tamersit, Soumia Mouffouk, Chaima Mouffouk, Faizul Azam, Rayan A. Mulla, Najeh Kharbatia, Mariusz Jaremko, Abdul‐Hamid Emwas, Nourhene Hamdaoui, Saoudi Mongi, Sara Mouffouk, Waffa Bouafia, Hamada Haba   +12 more
wiley   +1 more source

Phytochemical Analysis Using LC–MS/MS and Anticancer Activity of Asphodelus tenuifolius Roots: Cell Cycle Arrest, Apoptosis, and In Silico Insights

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
LC–HRMS/MS profiling of the hydroethanolic root extract of A. tenuifolius identifies 58 metabolites, including luteolin, emodin, luteolin‐7‐O‐β‐D‐glucoside, subaphyllin, and N‐trans‐feruloyltyramine. Integrated biological and computational analyses reveal apoptosis induction, G0/G1 cell‐cycle arrest, and multi‐target interactions, highlighting the ...
Racha Lydia Bouchouka, Farida Larit, Zahia Kabouche, Marlène Debiossat, Laurent Riou, Catherine Ghezzi, Francisco León, Ahmed Kabouche   +7 more
wiley   +1 more source

Ligand-Based Identification of Naturally Occurring 1E3G Receptor Inhibitors for Treating Prostate Cancer

Chemistry Proceedings
Background: Prostate cancer is one of the most prevalent malignancies worldwide, with the androgen receptor (1E3G) playing a central role in disease progression. Methodology: This study applied computational approaches to identify natural 1E3G inhibitors.
Abu Sayed, Ifteakhar Uddin, Sanjida Banu, Umme Ayman, Nabil Jonayeth Alvee, Mohammed Raihan Uddin, Joya Datta Ripa   +6 more
doaj   +1 more source

Essential Oil Compositions and Biological Activities of Broussonetia papyrifera Aerial Parts: An Integrated In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Essential oils from B. papyrifera stem bark and leaves were characterized by a high abundance of oxygenated sesquiterpenes, particularly spathulenol and (Z)‐dihydro‐apofarnesol. Both essential oils exhibited antioxidant and anti‐inflammatory activities, along with moderate cytotoxic effects.
Ty Viet Pham, Nguyen Thi Thoa, Nguyen Thi Huong, Le The Hoai, Tran Quang Hai, Shaza W. Shantier, Nguyen Thi Kim Thanh, Phan Hong Minh, Huynh Thi Ngoc Ni, Vo Thi Dung, Ninh The Son   +10 more
wiley   +1 more source

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]

, 2011
Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines, Sánchez-Monge Laguna de Rins, Rosa, Diaz Rodriguez, Isabel, Herrero, Ignacio, Carrillo Gil, Laura, Martinez Muñoz, Manuel   +5 more
core   +1 more source