Results 61 to 70 of about 610,579 (177)

In silico Analysis of Phytocompounds from Plumbago auriculata, Gymnema sylvestre, and Andrographis paniculata as Potential Inhibitors of NDM-1 in Klebsiella pneumoniae [PDF]

EPJ Web of Conferences
New Delhi metallo-β-lactamase-1 (NDM-1) is a major determinant of antibiotic resistance responsible for hydrolyzing β-lactam antibiotics, including carbapenems, in Klebsiella pneumoniae.
Ahmed Ramzan, Afsha Noor, Alam Rabiul, Singh Laishram Shantikumar, Chellapandi Karuppasamy, Thongmee Sirikanjana   +5 more
doaj   +1 more source

Antimalarial Phytochemicals Identification from Euphorbia Hirta against Plasmepsin Protease: an In Silico Approach [PDF]

Folia Medica, 2019
Background: Aspartic protease found in plasmodium parasites such as plasmepsin I, II and IV plays an important role in the degradation of hemoglobin. The studies have shown that effective drug must be able to inhibit more than one type of plasmepsin to ...
Ashish P. Shah, Ghanshyam R. Parmar, Girish U. Sailor, Avinash K. Seth   +3 more
doaj   +3 more sources

Identification of Anastatica hierochuntica L. Methanolic-Leaf-Extract-Derived Metabolites Exhibiting Xanthine Oxidase Inhibitory Activities: In Vitro and In Silico Approaches

Metabolites
There is a growing interest in the discovery of novel xanthine oxidase inhibitors for gout prevention and treatment with fewer side effects. This study aimed to identify the xanthine oxidase (XO) inhibitory potential and drug-likeness of the metabolites ...
Saranya Rameshbabu, Zeyad Alehaideb, Sahar S. Alghamdi, Rasha S. Suliman, Feras Almourfi, Syed Ali Mohamed Yacoob, Anuradha Venkataraman, Safia Messaoudi, Sabine Matou-Nasri   +8 more
doaj   +1 more source

Free Phenolic Hydroxyl Groups Govern the Anticancer Activity of α‐Mangostin: A Structure–Activity Relationship Insight

ChemFoodChem, Volume 2, Issue 3, September 2026.
Free phenolic hydroxyl groups in the chemical structure of the natural xanthone α‐mangostin (MGT) contribute positively to achieving the anticancer profile against murine colon cancer, murine triple negative breast cancer, and human osteosarcoma cancer. ABSTRACT The α‐mangostin (MGT) is a natural xanthone obtained from the pericarp of mangosteen fruit (
Otávio Augusto Chaves, Afonso Santine M. M. Velez, Lívia Stenico, Douglas Chaves de Alcântara Pinto, Debora Decote‐Ricardo, Eliezer Avila Gandra, Marco Edilson Freire de Lima, Carlos Serpa   +7 more
wiley   +1 more source

Action of PROTOX inhibitors herbicide on the development, lodging and yield of soybean [PDF]

, 2016
A soja é a espécie leguminosa mais importante mundialmente e por isso investimentos em tecnologia são necessários para o aumento da produtividade e redução de fatores adversos à cultura.
Gallon, Mateus, Silva, Henrique Luis da, Diesel, Francielli, Buzzello, Géderson Luiz, Trezzi, Michelangelo Muzell   +4 more
core   +1 more source

Manejo de Bidens subalternans resistente aos herbicidas inibidores da acetolactato sintase Management of Bidens subalternans resistant to acetolactate synthase inhibitor herbicides

Planta Daninha, 2003
A extensão das áreas com seleção de populações de plantas daninhas resistentes a herbicidas tem aumentado rapidamente no Brasil nos últimos anos, sendo citado como causa principal desta seleção a recomendação inadequada de produtos.
D.L.P. Gazziero, C.E.C. Prete, M. Sumiya
doaj   +1 more source

Phytochemical Profiling and Antibacterial Activity of Moroccan Monofloral Honeys Against Multidrug‐Resistant Uropathogens: In Vitro, ADMET, Molecular Docking, and Molecular Dynamics Approaches

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Multidrug‐resistant bacteria infections require alternative antimicrobial strategies. This study evaluated the phenolic composition, antibacterial activity, and in silico properties of four Moroccan monofloral honeys. Carob honey showed the greatest phenolic diversity, whereas citrus honey contained the lowest polyphenolic content.
Mourad Chikhaoui, Aziz Galman, Ahmed Chetoui, Oussama Khibech, Mohamed Reda Kachmar, Toufik Bouddine, Mohamed Bouhrim, Fahd A. Nasr, Mohammed Al‐Zharani, Ashraf Ahmed Qurtam, Rachid Lotfi, Houda El Hajjouji   +11 more
wiley   +1 more source

Differential effects of low molecular weight inhibitors on the conformation and the immunologic function of the adhesion receptor LFA-1 [PDF]

, 2004
Previous studies of our group 1,2 and by others 3 on the isolated ligand binding domain of LFA-1 (αL I domain) have suggested that some LFA-1 inhibitors act allosterically while other inhibitors were proposed to competitively block the LFA- 1/ligand ...
Welzenbach, Karl Albert
core   +1 more source

Transcriptomic Analysis Reveals Core Genes and Mechanisms Linking Grilled Food Toxicants (4‐HNE, BaP, PhIP) to NASH‐HCC Progression

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This study identifies a six‐gene signature (GSTA1, EPHX1, CYP2E1, GPX3, ALB, TF) that mediates how grilled food toxicants (4‐HNE, BaP, PhIP) synergistically drive NASH‐to‐HCC progression via oxidative stress, metabolic dysfunction, and immune microenvironment remodeling, providing a robust diagnostic nomogram for early risk stratification.
Bingbing Qin, Ye Zhang, Na Li, Jing Li, Yuehua Luo, Xi Tang, Ruisheng Zhou, Tianqi Cui, Ying Tang   +8 more
wiley   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Wosikowski, K., Probst, C., Sander, C. A., Degitz, K., Schuh, T., Flaig, M. J., Braungart, E., Douwes, K., Magdolen, V., C.A. Sander, C. Probst, K. Wosikowski, K. Degitz, T. Schuh, R. Besch, E. Braungart, V. Magdolen, M.J. Flaig, K. Douwes   +19 more
core   +2 more sources