Results 141 to 150 of about 102,782 (296)

Arsenic oxidation and bioaccumulation by the acidophilic protozoan, Euglena mutabilis, in acid mine drainage (Carnoulès, France)

, 2004
International audienceIn the acid stream (pH 2.5–4.7) originating from the Carnoulès mine tailings, the acidophilic protozoan Euglena mutabilis grows with extremely high sulfate (1.9–4.9 g/l), iron (0.7–1.7 g/l) and arsenic concentrations (0.08–0.26 g/l).
Personné, Jean-Christian, Leblanc, Marc, Elbaz-Poulichet, Françoise, Bruneel, Odile, Casiot, Corinne   +4 more
core   +1 more source

Selenium‐Containing 1,4‐Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple‐Negative Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4‐naphthoquinone, which serves as a precursor for numerous natural and synthetic compounds with potent antitumor properties.
Eduardo Angulo‐Elizari, Asif Raza, Hannah Johnson, Nuria Martínez‐Sáez, Ignacio Encío, Arun K. Sharma, Carmen Sanmartín, Daniel Plano   +7 more
wiley   +1 more source

Unusual MRI features in a case of presumed canine tick‐borne meningoencephalomyelitis

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract A 7‐year‐old, standard, wire‐haired dachshund presented with quickly progressive multifocal central nervous system signs, which localised to the brainstem and cervical myelopathy, including reduced cervical and thoracic limb muscle tone and withdrawal reflexes. Magnetic resonance imaging revealed bilateral, approximately symmetric, T2‐weighted
Jon Prager, Alex Smith, Hélène Vandenberghe   +2 more
wiley   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

Recent highlights in anti-protozoan drug development and resistance research

, 2012
This article summarizes the highlights of research presented in January, 2012, at the Keystone Symposium on “Drug Discovery for Protozoan Parasites” held in Santa Fe, New Mexico.
Avery, Vicky, Buckner, Fred, Buckner, Frederick S., Waters, N.C., Waters, Norman C., Avery, Vicky M., Buckner, Frederick S, Avery, Vicky M, Waters, Norman C   +8 more
core   +1 more source

Mass spectrometry proteomics for studying mitostasis

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Maintaining mitochondrial integrity and function is fundamental to cellular homeostasis. Cells rely on coordinated protein quality control (QC) systems—including intricate chaperone‐protease networks, the ubiquitin‐proteasome system, and cytosolic surveillance pathways—that together form a dynamic, cell‐wide mitostasis network governing the ...
Lakshita Sharma, Sristi Chakroborty, Hirak Das, Silke Oeljeklaus, Julian Bender, Bettina Warscheid   +5 more
wiley   +1 more source

When can AlphaFold predict the oligomeric states of proteins?

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Homooligomerisation is a prevalent and important process that many proteins undergo to form the quaternary structures required for biological function. However, determining oligomeric states and structures experimentally remains technically challenging and time‐consuming for many proteins.
Yiechang Lin, Ciara Wallis, Ben Corry
wiley   +1 more source

Evaluation of the Utilization Pattern of Veterinary Drugs in Selected Veterinary Clinics of Mekelle City, Tigray, Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Veterinary drug utilization patterns were assessed in three veterinary clinics in Mekelle City, Ethiopia. Antimicrobials, particularly oxytetracycline, constitute the majority of prescriptions, followed by anthelmintics. Drug prescribing frequently relies on tentative diagnosis rather than evidence‐based diagnostic procedures.
Helen Hagos, Mebrahtu Weldegebriel, Hagazi Fantay, Haftom Yirga Tsegay   +3 more
wiley   +1 more source

Identification of Distinct Interacting Proteins of Giardia lamblia Centrins Using Yeast Two‐Hybrid Assays

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Giardia lamblia, a protozoan parasite that causes diarrhea in humans, contains two centrins implicated in cellular morphology and cell division. To identify proteins interacting with each G. lamblia centrin (GlCent), we performed a yeast two‐hybrid assay.
Mee Young Shin, Juri Kim, Soon‐Jung Park   +2 more
wiley   +1 more source

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor. [PDF]

Acta Crystallogr F Struct Biol Commun
The production, crystallization and 1.8 Å resolution crystal structure of macrophage migratory inhibitory factor from P. vivax are reported.Plasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory ...
Nair A, Lin M, Srivastava A, Liu L, Cooper A, Battaile K, Harmon E, Myler PJ, Staker BL, Lovell S, Chakafana G, Asojo OA.   +11 more
europepmc   +2 more sources