Results 141 to 150 of about 78,604 (242)

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

The Role of Biofilm-Derived Compounds in Microbial and Protozoan Interactions. [PDF]

Microorganisms
Mahapatra S, Ankri S.
europepmc   +1 more source

Toxoplasma gondii‐Derived Soluble Factors Induce G2/M Phase Accumulation and p53‐Associated Mitochondrial Apoptosis in Human Umbilical Cord Mesenchymal Stem Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT Toxoplasma gondii infection poses potential risks to stem cell‐based therapeutic applications; however, the effects of parasite‐derived soluble factors on mesenchymal stem cells remain unclear. Here, we investigated the impact of T. gondii‐derived soluble factors (Tg‐SFs) on human umbilical cord‐derived mesenchymal stem cells (hUC‐MSCs).
Wei Zhou, Tingyu Chen, Ziping Yang, Jinjing Huang, Xinyi Lai, Jie Liu, Jiaqi Chu, Juanhua Quan   +7 more
wiley   +1 more source

Molecular Prevalence and Genetic Characterization of Bovine Tick-Borne Protozoa in Thai and Imported Beef Cattle in Thai-Myanmar Border and Infesting Ticks from Kanchanaburi Province, Thailand. [PDF]

Pathogens
Bhadury P, Do T, Pilean N, Chimnoi W, Kamyingkird K, Xuan X, Inpankaew T.   +6 more
europepmc   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Comparative evaluation of Midi Parasep^® Solvent Free and the Ritchie concentration technique for helminth and protozoa visualisation in clinical stool samples. [PDF]

Parasit Vectors
Rubio Maturana C, Zarzuela Serrat F, Goterris L, Martínez-Vallejo P, Mediavilla A, Silgado A, Rovira-Plujà J, Muixí M, Vila-Olmo N, José-Villar SMS, Larrosa N, Sulleiro E.   +11 more
europepmc   +1 more source

Glycosylphosphatidylinositols of Protozoan Parasites

Trends in Glycoscience and Glycotechnology, 2012
Tsai, Y., Grube, M., Seeberger, P., Varón Silva, D.   +3 more
openaire   +3 more sources

Occurrence of Antibodies Anti‐Toxoplasma gondii in Captive Non‐Human Primates From Pernambuco State, Brazil

Journal of Medical Primatology, Volume 55, Issue 4, August 2026.
ABSTRACT Wildlife captive populations are important tools for threatened species conservation, and early identification of diseases must be prioritized. In this study, we test for the presence of anti‐Toxoplasma gondii antibodies in non‐human primates at a Zoo from Pernambuco State, Brazil.
Marcio André Silva, Hilda Fátima Jesus Pena, Herbert Sousa Soares, Dênisson Silva Souza, Solange Maria Gennari, Jean Carlos Ramos Silva   +5 more
wiley   +1 more source

Bivalve mollusks as sentinels: Molecular detection of <i>Toxoplasma gondii</i> on Maranhão Island in northeastern Brazil. [PDF]

Int J Parasitol Parasites Wildl
Silva EMC, Silva ALP, Gonçalves LR, Santos GG, Costa Oliveira MDS, Machado RZ, Chaves Bezerra NP, de Carvalho Neta AV.   +7 more
europepmc   +1 more source

Attenuation of Tau Hyperphosphorylation by Chronic Toxoplasma gondii Infection in a Mouse Model of Alzheimer's Disease

Parasite Immunology, Volume 48, Issue 8, August 2026.
ABSTRACT Alzheimer's disease (AD) is characterized by amyloid‐β (Aβ) peptide accumulation and tau protein‐mediated neurodegeneration, and neuroinflammation is increasingly recognized as a major process associated with tau pathology. Chronic Toxoplasma gondii infection reduces amyloid accumulation in AD models through immune modulation, but its stage ...
Seung‐Hwan Seo, Ji‐Eun Lee, Eun‐Ji Cho, Eun‐Hee Shin   +3 more
wiley   +1 more source