Results 61 to 70 of about 460,327 (300)

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant, A Dube, A Mehta, A Mukherjee, AB Sidhu, AC Coelho, AH Fairlamb, Ashutosh, B Gourbal, B Vergnes, Basudha Khanal, BJ Mookerjee, C Brochu, C Dumas, CS Ferreira, D Legare, DM Weinreich, F Chappuis, F Frezard, G Mandal, Graham H. Coombs, H Denton, H Shim, Hideo Imamura, HW Murray, J Alvar, J Hellemans, J Mikus, J Tovar, JC Mottram, JC Munday, Jean-Claude Dujardin, JM Kelly, K Ait-Oudhia, K Grondin, KC Carter, Kirstyn Brunker, KW Tintaya, L Flohe, M Maharjan, M Samant, M Vanaerschot, Manu Vanaerschot, MK Mittal, ML Cunningham, MR Ariyanayagam, MR Perry, N Beerenwinkel, N Singh, N Van Meirvenne, P Baiocco, PJ Alcolea, PR Romao, R Hadighi, R Lira, R Mukhopadhyay, R Rojas, R Singh, RA Williams, RI da Luz, RL Krauth-Siegel, RL Krauth-Siegel, S Borrell, S Decuypere, S Dey, S Gagneux, S Mandal, S Muller, S Rais, S Rijal, S Sundar, S Wyllie, S Wyllie, S Yan, S Yan, Saskia Decuypere, Suman Rijal, Sylke Müller, T Downing, T Downing, T Laurent, T Nozaki, Timothy G. Geary, V Adaui, V Yardley, Y Zhou   +85 more
core   +7 more sources

Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites

Parasites & Vectors, 2011
Apoptosis-like programmed cell death (PCD) has recently been described in multiple taxa of unicellular protists, including the protozoan parasites Plasmodium, Trypanosoma and Leishmania.
Reece Sarah E, Sajid Mohammed, Kaczanowski Szymon   +2 more
doaj   +1 more source

Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding [PDF]

Open Biology, 2017
The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The evolutionary pressure associated with establishing and maintaining an infection and transmission to vector or host has shaped parasite morphology.
Jack Sunter, Keith Gull
doaj   +1 more source

Zoonotic and other gastrointestinal parasites in cats in Lumajang, East Java, Indonesia

Infectious Disease Reports, 2020
Relationship between humans and cats has negative impact associates with zoonotic diseases. It is the reason why studies on the prevalence of gastrointestinal (GI) parasites in cats are important.
Izzu Ar-Rifqi Rabbani, Fairuz Jihan Mareta, Kusnoto, Poedji Hastutiek, Nunuk Dyah Retno Lastuti, Mufasirin, Suharsono, I Komang Wiarsa Sardjana, Moh. Sukmanadi, Lucia Tri Suwanti   +9 more
doaj   +1 more source

Enteric Protozoan Parasites in Rural Areas of Bandar-Abbas, Southern Iran: Comparison of Past and Present Situation [PDF]

Iranian Journal of Public Health, 2011
Background: The main goal was to address the prevalence of enteric protozoan parasites in rural areas of Bandar- Abbas, southern Iran and to compare the results with the only conducted study in 1978.
A Bairami Kuzehkanani, S Rezaei, Z Babaei, M Niyyati, SN Hashemi, M Rezaeian   +5 more
doaj   +1 more source

The proteasome as a target for protozoan parasites

Expert opinion on therapeutic targets, 2019
Introduction: The proteasome is a multi-subunit enzyme complex responsible for the turnover of short-lived, abnormal or damaged proteins in eukaryotic cells. As organisms that undergo rapid growth and cell division, protozoan parasites exist on the knife-
S. Xie, L. Dick, A. Gould, S. Brand, L. Tilley   +4 more
semanticscholar   +1 more source

The cytoskeleton of protozoan parasites

Current Opinion in Cell Biology, 1996
There are seven processes that require a cytoskeleton in protozoan parasites: nuclear division, cytokinesis, cell shape determination, motility, invasion, flagellar movement of sperm, and intracellular transport.
L G, Tilney, M S, Tilney
openaire   +2 more sources

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie International Edition, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +1 more source

Investigating the evolution of apoptosis in malaria parasites: the importance of ecology [PDF]

, 2010
Apoptosis is a precisely regulated process of cell death which occurs widely in multicellular organisms and is essential for normal development and immune defences.
Colegrave, Nick, Khan, Shahid M., Pollitt, Laura C., Reece, Sarah E., Sajid, Mohammed   +4 more
core   +2 more sources

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source