Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Listening to the experiences of the long-term displaced [PDF]
Forced Migration Review, 2009 This article offers insights from people who have lived inprotracted displacement situations, based on evidencegathered by the Listening Project.
Dayna Brown, Kathryn Mansfield
doaj
"I don't know if we'll ever live in harmony": a mixed-methods exploration of the unmet needs of Syrian adolescent girls in protracted displacement in Lebanon. [PDF]
Arch Public Health, 2021 Davison CM +3 more
europepmc +1 more source
Exposure Outliers: Children, Mothers, and Cumulative Disaster Exposure in Louisiana [PDF]
, 2019 Only a limited number of studies have explored the effects of cumulative disaster exposure—defined here as multiple, acute onset, large-scale collective events that cause disruption for individuals, families, and entire communities.
Mohammad, Lubna, Peek, Lori
core +2 more sources
Monte Carlo Simulation of Long Chain Polymer Melts: Crossover from Rouse to Reptation Dynamics
, 2000 We present data of Monte Carlo simulations for monodisperse linear polymer chains in dense melts with degrees of polymerization between N=16 and N=512.
Baschnagel, J. +3 more
core +2 more sources
European emergency coordination. ZEI Discussion Paper C259 2020 [PDF]
, 2020 The European elections in 2019 sent two messages. Firstly, Europe is stronger than what its opponents thought it would be. Despite major challenges like Brexit and migration, the results of the election demonstrated strong European cohesion.
Stylianides, Christos
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Forced Migration Review, 2010 The views of Sri Lankan refugees in India challenge some of the assumptions inherent in promoting repatriation as the most desirable durable solution to protracted displacement.
John Giammatteo
doaj
Impact of Protracted Displacement on Delay in the Diagnosis Associated with Treatment Outcomes: A Cross-Sectional Study in Internally Displaced Tuberculosis Patients of Pakistan. [PDF]
Int J Environ Res Public Health, 2021 Khan FU +8 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source