Results 61 to 70 of about 730,024 (299)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Implementation of intimate partner violence education for adolescents with spina bifida

Journal of Pediatric Rehabilitation Medicine, 2019
OBJECTIVE: Intimate partner violence (IPV) prevention among adolescent patients with disability is needed, yet rarely discussed in the clinical setting.
Tal Levin-Decanini, Elizabeth Miller, Amy Houtrow, Lisa Kreashko, Brenda Cassidy   +4 more
doaj   +1 more source

Best Practices in Mental Health at Corrections Facilities [PDF]

, 2011
Police, court personnel, and correctional staff interact with, stabilize, and treat more persons with mental illness than any other system in America—making criminal justice agencies the largest mental health provider in the United States. Yet a wide gap
Jain, Sahil
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Opioid prescriptions following behavioral health training among primary care providers

BMC Medical Education
Background Overdose deaths due to opioids are a major concern in the United States. Physicians often report inadequate training in chronic pain and substance use disorder management. Here, we evaluate whether a specialized program, the Train New Trainers
Shutong Huo, Tim A. Bruckner, Abhery Das, Glen L. Xiong, David Marcovitz, Ariel B. Neikrug, Robert McCarron   +6 more
doaj   +1 more source

Plain language communication as a priority competency for medical professionals in a globalized world

Canadian Medical Education Journal, 2018
This brief report aims to highlight the impact of globalization – the international movement of goods, people, and ideas – on patient-provider communication in medical training and practice, and how the implementation of plain language communication ...
Fiona Warde, Janet Papadakos, Tina Papadakos, Danielle Rodin, Mohammad Salhia, Meredith Giuliani   +5 more
doaj   +1 more source

The prevalence of malocclusion in Maltese schoolchildren as measured by the Index of Orthodontic Treatment Need [PDF]

, 2007
The Index of Orthodontic Treatment Need (IOTN), a widelyused, standardised epidemiological tool was used to determine the prevalence of malocclusion in Maltese schoolchildren.
Camilleri, Simon, Mulligan, Kevin M.
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Understanding mechanisms of multi-level implementation strategies for autism interventions in a randomized trial across service systems

Implementation Science
Background Understanding the effectiveness of implementation strategies to support uptake of evidence-based interventions (EBIs) requires examining activation of mechanisms targeted by implementation strategies.
Aubyn C. Stahmer, Anna S. Lau, Scott Roesch, Elizabeth Rangel, Gregory A. Aarons, Lauren Brookman-Frazee   +5 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source