Results 101 to 110 of about 2,293,849 (307)

The incidence, prevalence and trends of Chronic Kidney Disease and Chronic Kidney Disease of uncertain aetiology (CKDu) in the North Central Province of Sri Lanka: an analysis of 30,566 patients

open access: yesBMC Nephrology, 2019
BackgroundChronic Kidney Disease (CKD) of uncertain origin (CKDu) has affected North Central Province (Anuradhapura and Polonnaruwa districts) of Sri Lanka. The cause is still unknown. The objective of this study was to describe the incidence, prevalence
A. Ranasinghe   +9 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Irrigation Expansion and Rural Transformation in China: Evidence of Provincial Data in 1978–2018

open access: yesAsia & the Pacific Policy Studies
The role of irrigation expansion in facilitating rural transformation has been widely documented, yet quantitative studies remain rather limited. Based on the statistical data from 27 provinces in China, this paper analyses the correlation between ...
Pengfei Shi, Jikun Huang
doaj   +1 more source

Chişinăul în anii Primului Război Mondial: de la periferia Imperiului Rus la provincia României Mari [PDF]

open access: yesPlural: History, Culture, Society, 2018
Between 1914 and 1921, the population inhabiting the region of Bessarabia witnessed, although from behind the frontline, the world conflagration, which was followed by major political changes that detached the region from the Russian Empire, then created
Svetlana Suveică, Virgil Pâslariuc
doaj  

Reference couple gold deposit — placer as a basis for forecasting of the new gold deposits in Amur river basin

open access: yesИзвестия высших учебных заведений: Геология и разведка, 2019
About 1400 placers and several dozens of ore gold deposits are known in the Amur gold-bearing province. Placers are to a large degree worked out, so the future of the province is seen to be in the discovery of the new gold deposits.
V. A. Stepanov
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Residents’ Awareness of Family Doctor Contract Services, Status of Contract with a Family Doctor, and Contract Service Needs in Zhejiang Province, China: A Cross-Sectional Study

open access: yesInternational Journal of Environmental Research and Public Health, 2019
In China, family doctor services originated in 2009. After two years, the Chinese government proposed the establishment of a family doctor contract system suitable for China’s national conditions.
X. Shang   +9 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

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