Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Textile Sweatshops; Adidas, Bali Intimates, Hanesbrands Inc., Piege Co (Felina Lingerie), Quiksilver, Regina Miracle Speedo, Walcoal America Inc., and Wal-Mart Made In China [PDF]
Describes poor working conditions in four textile and garment factories in the Guangdong Province despite companies’ assertions of ethical work standards.
China Labor Watch
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Further evidence of community education effects on fertility in sub-Saharan Africa
BACKGROUND Earlier investigations have shown that a woman's chance of having a child, or various proximate determinants of her fertility, are influenced by the socioeconomic resources in the community in which she lives, net of her own resources ...
Øystein Kravdal
doaj
This article explores the characteristics of cultural development in the provinces during the 1950-ies and 1960-ies of the XX century within the context of everyday life in the Soviet Union.
O. D. Popova, M. O. Maslovsky
doaj +1 more source
The development of the Huambo Province in Angola - The application of a spatial interaction model to simulate the movement from autarky to external integration [PDF]
Huambo province in Angola has been detached from the outside world since the begining of the nineties. First due to the civil war in Angola and from then on due to the degradation of the roads and destruction of the railways.
Silvia Amaral, Tomaz Dentinho
core
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Dzhagdy-Selemdzinskaya metallogemc zone is shown to be the one of the most productive gold-bearing zones in Priamurskaya province. The placer and ore deposits mined in the area are estimated to be about 350 t of gold, including 293,811 of placer and 57 ...
V. A. Stepanov, A. V. Melnikov
doaj +2 more sources
Building Agricultural Capacity in Newfoundland and Labrador [PDF]
Newfoundland and Labrador faces considerable challenges in maintaining a consistent and reliable food supply. The lack of locally produced food has resulted in the province’s dependency on imported foods.
Quinlin, A. James
core

