Results 61 to 70 of about 1,824,701 (322)

Proximal boosting and its acceleration

, 2020
Gradient boosting is a prediction method that iteratively combines weak learners to produce a complex and accurate model. From an optimization point of view, the learning procedure of gradient boosting mimics a gradient descent on a functional variable ...
Boyer, Claire, Fouillen, Erwan, Sangnier, Maxime   +2 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Challenges in the management of iliofemoral deep vein thrombosis in a resource limited setting: a case series

The Pan African Medical Journal, 2014
Iliofemoral deep vein thrombosis is a medical emergency associated with pulmonary embolism, severe postthrombotic morbidity and increased rates of recurrence.
Emeka Blessius Kesieme, Peter Okokhere, Sylvester Eluehike, Peter Isabu   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Medio-lateral inclination of proximal and distal articular surface of the radius

Asian Journal of Medical Sciences, 2016
Background: The radius, also known as the radial bone, is the shorter of the two bones of the forearm. It has proximal and distal articulations with the humerus, ulna, and carpal bones.
Ahmed Al-Imam
doaj   +1 more source

Electrophysiological features of repetitive focal Purkinje ventricular arrhythmias originating from the proximal cardiac conduction system

Journal of Arrhythmia, 2022
Background Focal Purkinje ventricular arrhythmias (VAs) might originate from the vicinity of the proximal portion of the cardiac conducting system. This study aimed to clarify the features associated with focal Purkinje VAs originating from the proximal ...
Shota Ikeda, Kazuo Sakamoto, Daigo Tokudome, Shunsuke Kawai, Kiyohiro Ogawa, Kazuhiro Nagaoka, Susumu Takase, Shinya Kowase, Yasushi Mukai, Akihiko Nogami, Hiroyuki Tsutsui   +10 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Prevalence of OXIS Contacts between the Primary Molars in 3 to 9 Years Old Children: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Interproximal contacts between primary teeth have traditionally been reported as broad and flat. A new system of classification for contacts called OXIS- O (open contact), X (point contact), I (straight contact), and S (curved contact) was ...
J Jasmin Winnier, Reema Manoj, Amil Joshi, Sonal J Tandel, Arwa Soni, Sanjana R Kodical   +5 more
doaj   +1 more source