Results 71 to 80 of about 1,196,310 (302)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Comparative study on outcomes of reverse total shoulder arthroplasty in rotator cuff arthropathy versus nonreconstructable proximal humeral fractures

Alexandria Journal of Medicine
Context Reverse total shoulder arthroplasty (RTSA) has shown great success in treating diverse shoulder ailments. Aims Investigates the clinical outcomes of RTSA in managing rotator cuff arthropathy (RCA) compared to non-reconstructable proximal humeral ...
Mohamed G. Morsy, Ayman S. Ismail, Mohamed M.A. Heif, Omar K.M. Aboelfath Sabbah   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Regional Specific Evidence for Memory-Load Dependent Activity in the Dorsal Subiculum and the Lateral Entorhinal Cortex

Frontiers in Systems Neuroscience, 2017
The subiculum and the lateral entorhinal cortex (LEC) are the main output areas of the hippocampus which contribute to spatial and non-spatial memory.
Shih-pi Ku, Nozomu H. Nakamura, Nozomu H. Nakamura, Nicolas Maingret, Liv Mahnke, Liv Mahnke, Liv Mahnke, Motoharu Yoshida, Motoharu Yoshida, Magdalena M. Sauvage, Magdalena M. Sauvage, Magdalena M. Sauvage, Magdalena M. Sauvage   +12 more
doaj   +1 more source

Best Proximity Point Results for MK‐Proximal Contractions [PDF]

Abstract and Applied Analysis, 2012
Let A and B be nonempty subsets of a metric space with the distance function d, and T : A → B is a given non‐self‐mapping. The purpose of this paper is to solve the nonlinear programming problem that consists in minimizing the real‐valued function x ↦ d(x, Tx), where T belongs to a new class of contractive mappings.
Jleli, Mohamed, Karapınar, Erdal, Samet, Bessem   +2 more
openaire   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Valsiner’s Zone Theory As The Teachers’ Zone Of Proximal Development [PDF]

, 2011
The research, develop and validate the theory and development of teacher educators of mathematics learning will lead to a better understanding of how expertise is developed in carrying out professional duties. In doing so, will provide evidence to inform
Rustanto , Rahardi
core  

Electrophysiological features of repetitive focal Purkinje ventricular arrhythmias originating from the proximal cardiac conduction system

Journal of Arrhythmia, 2022
Background Focal Purkinje ventricular arrhythmias (VAs) might originate from the vicinity of the proximal portion of the cardiac conducting system. This study aimed to clarify the features associated with focal Purkinje VAs originating from the proximal ...
Shota Ikeda, Kazuo Sakamoto, Daigo Tokudome, Shunsuke Kawai, Kiyohiro Ogawa, Kazuhiro Nagaoka, Susumu Takase, Shinya Kowase, Yasushi Mukai, Akihiko Nogami, Hiroyuki Tsutsui   +10 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Emerging role of preputial vascular pattern and postoperative microvessel density in cases of proximal hypospadias: A pilot study

Indian Journal of Pathology and Microbiology, 2017
Introduction: Understanding of anatomical vascular patterns and anatomy of prepuce is critical for a good outcome in hypospadias surgery. A well-vascularized neourethral and preputial flaps used for repair are exceptionally important for a successful ...
Vishrut Narang, Amita Sen, Minakshi Bhardwaj   +2 more
doaj   +1 more source