Results 91 to 100 of about 1,196,310 (302)

Proximal Mappings

open access: yesJournal of Approximation Theory, 1998
The author studies subdifferentiability of the Baire and Mosco-Yosida approximates to a nonconvex function in a Banach space setting. Close results in Hilbert space are given [\textit{F. H. Clarke, R. J. Stern} and \textit{P. R. Wolenski}, J. Convex Anal. 2, No. 1-2, 117-144 (1995; Zbl 0881.49008)].
openaire   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Clinical relevance of serum lysozyme in sarcoidosis with kidney impairment

open access: yesImmunological Medicine
The clinical significance of serum lysozyme in sarcoidosis remains unclear. This study aimed to evaluate the clinical characteristics and kidney function of sarcoidosis patients with elevated serum lysozyme.
Shunichiro Hanai   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Tubularized Incised Plate Urethroplasty for Proximal Hypospadias

open access: yes, 2009
Objective To review our experience of using the tubularized incised plate (TIP) urethroplasty (useful in the treatment of distal hypospadias) to treat proximal hypospadias.
陳世乾   +1 more
core  

The Dual-Gate Lumen Model of Renal Monoamine Transport [Expression of Concern]

open access: yesNeuropsychiatric Disease and Treatment, 2020
Hinz M, Stein A, Uncini T. Neuropsych Dis Treat. 2010;6:387–392. The Editor-in-Chief and Publisher of Neuropsychiatric Disease and Treatment wish to issue an Expression of Concern for the published article.
Hinz M, Stein A, Uncini T
doaj  

Infinite games and quasi-uniform box products

open access: yesApplied General Topology, 2019
We introduce new infinite games, played in a quasi-uniform space, that generalise the proximal game to the framework of quasi-uniform spaces.  We then introduce bi-proximal spaces, a concept that generalises proximal spaces to the quasi-uniform setting ...
Hope Sabao, Olivier Olela Otafudu
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The strength of weak proximity

open access: yesJournal of Discrete Algorithms, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Giuseppe Di Battista   +2 more
openaire   +6 more sources

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