Results 111 to 120 of about 1,196,310 (302)

Proximal algorithms for nuclear norm system identification [PDF]

, 2022
In this thesis, we present four proximal algorithms for the solution of a nuclear norm optimization problem. Respect to other papers, we solve a more generic version of this problem.
Faccio, Chiara
core  

Calculus Rules for V-Proximal Subdifferentials in Smooth Banach Spaces

Journal of Function Spaces, 2016
In 2010, Bounkhel et al. introduced new proximal concepts (analytic proximal subdifferential, geometric proximal subdifferential, and proximal normal cone) in reflexive smooth Banach spaces.
Messaoud Bounkhel
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Kullback-Leibler Proximal Variational Inference [PDF]

We propose a new variational inference method based on a proximal framework that uses the Kullback-Leibler (KL) divergence as the proximal term. We make two contributions towards exploiting the geometry and structure of the variational bound. Firstly, we
Fua, Pascal, Khan, Mohammad Emtiyaz, Fleuret, François, Baqué, Pierre Bruno   +3 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Sensitivity analysis of a cemented hip stem to implant position and cement mantle thickness

, 2013
Patient-specific finite element models of the implanted proximal femur can be built from pre-operative computed tomography scans and post-operative X-rays.
Shi, Junfen, Taylor, Mark, Browne, Martin, Flivik, Gunnar, Strickland, Michael A.   +4 more
core   +1 more source

脑梗死患者上肢近端和远端早期运动功能恢复的影响因素分析Analysis of Influencing Factors for Early Motor Function Recovery of Proximal and Distal Upper Limbs in Patients with Cerebral Infarction

Zhongguo cuzhong zazhi
目的 探讨脑梗死患者上肢近端和远端早期运动功能恢复不良的影响因素。 方法 前瞻性纳入2023年11月—2024年12月福建医科大学附属第一医院神经内科收治的急性脑梗死伴上肢功能障碍患者，采用Fugl-Meyer运动功能评定量表上肢部分（Fugl-Meyer motor assessment-upper extremity，FMA-UE），分别于发病第3～7天和第8～12天进行间隔天数≥5 d的第1次和第2次评估，并收集相关人口统计学及临床资料。根据上肢运动功能恢复结局将患者分为近端恢复不良组 ...
叶珊珊, 林嘉莉, 林嘉滢, 钱佳煜, 贾杰YE Shanshan, LIN Jiali, LIN Jiaying, QIAN Jiayu, JIA Jie
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source