Results 131 to 140 of about 611,505 (395)

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Welcome to MEPE in the renal proximal tubule [PDF]

, 2010
Gérard Friedlander
openalex   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka, Michael Lawton, Tom Chu, Gary S. Friedman, Katrina Peron, Stefan R. Sultana, Warren E. Glaab, Nicholas M. P. King   +7 more
wiley   +1 more source

Effect of grape seed and flaxseed oils on kidney and testicular tissue in male rabbits exposed to tramadol-induced oxidative stress

Tikrit Journal of Pure Science
The study aimed to determine how tramadol affects oxidative stress and how flaxseed Oil (FSO) and grape seed oil (GSO) can enhance the biological functions of testicular and renal tissues in male rabbits exposed to tramadol-induced oxidative stress. The
Abbas Fadhil Khudhur , Aljassir Mohammed Jassim   +1 more
doaj   +1 more source

Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus [PDF]

, 2018
M. Giraud Billoud, Fernando Ezquer, J. Bahamonde, Marcelo Ezquer   +3 more
openalex   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling

Cell Communication and Signaling
Background Tubulointerstitial kidney disease associated microenvironmental dysregulation, like acidification, inflammation and fibrosis, affects tubule cells and fibroblasts.
Marie-Christin Schulz, Michael Kopf, Michael Gekle   +2 more
doaj   +1 more source

Potassium channels in renal proximal tubule [PDF]

Medicinski Podmladak, 2017
Potassium channels are a diverse family of membrane proteins which are present within all cells of the body. They contain two subunits α, which determine the structure of the channel, and β, which can modify the properties of the channel.
Kovačević Sanjin, Nešović-Ostojić Jelena   +1 more
doaj  

Triflocin, a novel inhibitor for the Na‐HCO₃ symport in the proximal tubule [PDF]

, 1994
Fouzia Belachgar, Philippe Hulin, T. Anagnostopoulos, Gabrielle Planelles   +3 more
openalex   +1 more source