The Relationship between Glomerular Filtration Rate and Sodium Reabsorption by the Proximal Tubule of the Rat Nephron [PDF]
, 1969 openalex +1 more source
Plasma Volume Expansion and Proximal Tubular Reabsorption of Salt and Water by Rat Kidney [PDF]
, 1966 Venous infusion of both hypertonic and isotonic solutions has been known to lead to diuresis and natriuresis. In recent micropuncture studies, attempts have been made to identify the tubular locus at which renal functions may be altered and to identify ...
Solomon, Sidney, Sonnenberg, Harald
core +1 more source
Urea Reabsorption by the Proximal Tubule of the Dog.
Experimental Biology and Medicine, 1965 Both micropuncture and tissue analytical techniques have been used extensively to study urea reabsorption by the renal tubule of the rat (1–3). These procedures have made it possible to quantitate urea reabsorption in various portions of the rat renal tubule.
openaire +3 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano +8 more
wiley +1 more source
Micropuncture Study of the Effect of Acute Reductions in Glomerular Filtration Rate on Sodium and Water Reabsorption by the Proximal Tubules of the Rat* [PDF]
, 1965 Sheldon Glabman +2 more
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Clinical Pharmacology &Therapeutics, EarlyView.Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK/TD) model using the largest polymyxin B‐treated critically ill patient population studied to inform polymyxin B ...
Patrick O. Hanafin +19 more
wiley +1 more source
A Microperfusion Study of Bicarbonate Accumulation in the Proximal Tubule of the Rat Kidney* [PDF]
, 1967 Norman Bank, Hagop S. Aynedjian
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A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys [PDF]
, 2019 Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (
Chen, Song +12 more
core +2 more sources
Streptozotocin induced hyperglycemia in the axolotl
Developmental Dynamics, EarlyView.Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen +2 more
wiley +1 more source
Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health
British Journal of Pharmacology, EarlyView., 2023 Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue +7 more
wiley +1 more source