Results 171 to 180 of about 53,118 (291)

TRAPPC2l Participates in Male Germ Cell Development by Regulating Cell Division

Cell Proliferation, EarlyView.
Trappc2l is crucial for maintaining the quiescent state of male gonocytes. In the absence of Trappc2l, the quiescent state of gonocytes is disrupted, leading to premature and abnormal initiation of meiosis, which consequently results in subsequent abnormalities in sperm development. ABSTRACT TRAPPC2L is a core subunit of the Transport Protein Particle (
Mengyue Wang, Jiayi Li, Bowen Liu, Zhiming Shen, Min Chen, Xiuhong Cui, Hongbin Liu, Fei Gao, Han Zhao   +8 more
wiley   +1 more source

Proximal Tubule Secretory Clearance, Injury, and Kidney Viability in Cirrhosis. [PDF]

Clin Transl Gastroenterol
Granda ML, Luitweiler E, Prince DK, Allegretti AS, Paine C, Pichler R, Sibulesky L, Biggins SW, Kestenbaum B.   +8 more
europepmc   +1 more source

A13C-n.m.r. investigation of the metabolism of amino acids in renal proximal convoluted tubules of normal and streptozotocin-treated rats and rabbits [PDF]

, 1989
A. W. H. Jans, R. Willem
openalex   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

A Focus on the Proximal Tubule Dysfunction in Dent Disease Type 1. [PDF]

Genes (Basel)
de Combiens E, Sakhi IB, Lourdel S.
europepmc   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease—A practical update for clinicians

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink, Dominique van Mil, Gozewijn D. Laverman, Hiddo J. L. Heerspink, Ron T. Gansevoort   +4 more
wiley   +1 more source

hTERT and SV40LgT Renal Cell Lines Adjust Their Transcriptional Responses After Copy Number Changes from the Parent Proximal Tubule Cells. [PDF]

Int J Mol Sci
Merrick BA, Brooks AM, Foley JF, Martin NP, Fannin RD, Gladwell W, Gerrish KE.   +6 more
europepmc   +1 more source

Modulation of phosphate absorption by calcium in the rabbit proximal convoluted tubule. [PDF]

, 1985
D. Rouse, W. N. Suki
openalex   +1 more source

Effects of dapagliflozin on sodium excretion, blood pressure and volume status in patients with type 2 diabetes and/or chronic kidney disease: The DAPASALT trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims We assessed the effects of dapagliflozin on natriuresis and blood pressure in patients with type 2 diabetes and chronic kidney disease (CKD) and evaluated the consistency of these effects across patients with type 2 diabetes without CKD and CKD without type 2 diabetes.
Jelle M. Beernink, Niels Jongs, Charlotte M. Mosterd, Rosalie A. Scholtes, Alyssa Caldwell‐McGee, Daniel Casillas, Lynette Driscoll, Peter J. Greasley, Cecilia Karlsson, Ann Hammarstedt, Vikas S. Sridhar, Marcel H. A. Muskiet, Gozewijn D. Laverman, David Z. I. Cherney, Petter Bjornstad, Daniel H. van Raalte, Hiddo J. L. Heerspink   +16 more
wiley   +1 more source