Results 71 to 80 of about 605,238 (303)

Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis.

Journal of the American Society of Nephrology, 2016
AKI increases the risk of developing CKD, but the mechanisms linking AKI to CKD remain unclear. Because proximal tubule injury is the mainstay of AKI, we postulated that proximal tubule injury triggers features of CKD. We generated a novel mouse model to
Koji Takaori, J. Nakamura, Shinya Yamamoto, Hirosuke Nakata, Y. Sato, Masayuki Takase, M. Nameta, Tadashi Yamamoto, A. Economides, K. Kohno, H. Haga, K. Sharma, M. Yanagita   +12 more
semanticscholar   +1 more source

Single-cell analysis of angiotensin-converting enzyme II expression in human kidneys and bladders reveals a potential route of 2019 novel coronavirus infection

Chinese Medical Journal, 2021
. Background:. Since 2019, a novel coronavirus named 2019 novel coronavirus (2019-nCoV) has emerged worldwide. Apart from fever and respiratory complications, acute kidney injury has been observed in a few patients with coronavirus disease 2019 ...
Wei Lin, Jue Fan, Long-Fei Hu, Yan Zhang, Joshua D. Ooi, Ting Meng, Peng Jin, Xiang Ding, Long-Kai Peng, Lei Song, Rong Tang, Zhou Xiao, Xiang Ao, Xiang-Cheng Xiao, Qiao-Ling Zhou, Ping Xiao, Yong Zhong, Peng Lyu.   +17 more
doaj   +1 more source

Modeling the Effects of Multiple Myeloma on Kidney Function [PDF]

, 2016
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populations involved.
arxiv   +1 more source

3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing

Frontiers in Physiology, 2017
Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a primary site of nephrotoxicity and resulting attrition in the drug development pipeline.
M. Gumz, Arohan R. Subramanya, R. Masereeuw, D. Nguyen, King Sm, Higgins Jw, Nino Cr, S. M. King, J. W. Higgins, C. Niño, Timothy R. Smith, Elizabeth Paffenroth, C. E. Fairbairn, Abigail Docuyanan, Vishal D. Shah, Alice E. Chen, S. Presnell   +16 more
semanticscholar   +1 more source

Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling. [PDF]

Cell Commun Signal
Background Tubulointerstitial kidney disease associated microenvironmental dysregulation, like acidification, inflammation and fibrosis, affects tubule cells and fibroblasts.
Schulz MC, Kopf M, Gekle M.
europepmc   +2 more sources

Inhalation of mercury vapor can cause the toxic effects on rat kidney [PDF]

, 2016
Dental amalgam has been used in dentistry as a filling material. The filler comprises mercury (Hg). It is considered one of the most important and widespread environmental pollutants, which poses a serious potential threat for the humans and animals ...
Akgul, Hayati Murat, Akgul, Nilgun, Altunkaynak, Berrin Zuhal, Altunkaynak, Muhammed Eyup, Deniz, Omur Gulsum, Unal, Deniz   +5 more
core   +1 more source

Formula for the Absorption Coefficient for Multi-Wall Nanotubes [PDF]

Physics Letters A 372, 3517 (2008), 2010
We present a formalism for calculating the absorption coefficient of a pair of coaxial tubules. A spatially nonlocal, dynamical self-consistent field theory is obtained by calculating the electrostatic potential produced by the charge density fluctuations as well as the external electric field.
arxiv   +1 more source

Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid Transporter-2 (FATP2).

Journal of the American Society of Nephrology, 2017
Albuminuria and tubular atrophy are among the highest risks for CKD progression to ESRD. A parsimonious mechanism involves leakage of albumin-bound nonesterified fatty acids (NEFAs) across the damaged glomerular filtration barrier and subsequent ...
Shenaz Khan, Pablo D. Cabral, W. Schilling, Zachary W Schmidt, Asif N Uddin, Amelia Gingras, S. Madhavan, J. Garvin, J. Schelling   +8 more
semanticscholar   +1 more source

Acute effect of prednisolone on renal handling of sodium. [PDF]

, 1973
The effect of prednisolone on renal handling of sodium (Na) was studied in rats under three experimental conditions: 1) hydropenia, 2) water diuresis, and 3) distal tubular blockade (DTB).
Halgrimson, CG, Popovtzer, MM, Robinette, J, Starzl, TE   +3 more
core   +1 more source

Self-assembly of artificial microtubules [PDF]

SOFT MATTER 8, 5666-5678 (2012), 2012
Understanding the complex self-assembly of biomacromolecules is a major outstanding question. Microtubules are one example of a biopolymer that possesses characteristics quite distinct from standard synthetic polymers that are derived from its hierarchical structure.
arxiv   +1 more source