Results 81 to 90 of about 684,958 (347)

User-friendly microfluidic system reveals native-like morphological and transcriptomic phenotypes induced by shear stress in proximal tubule epithelium

APL Bioengineering, 2023
Drug-induced nephrotoxicity is a leading cause of drug attrition, partly due to the limited relevance of pre-clinical models of the proximal tubule. Culturing proximal tubule epithelial cells (PTECs) under fluid flow to mimic physiological shear stress ...
Natalie N. Khalil, Andrew P. Petersen, Cheng J. Song, Yibu Chen, Kaelyn Takamoto, Austin C. Kellogg, Elaine Zhelan Chen, Andrew P. McMahon, Megan L. McCain   +8 more
doaj   +1 more source

MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury [PDF]

, 2016
Murine double minute-2 (MDM2) is an E3-ubiquitin ligase and the main negative regulator of tumor suppressor gene p53. MDM2 has also a non-redundant function as a modulator of NF-kB signaling. As such it promotes proliferation and inflammation.
Anders, Hans-Joachim, Ebrahim, Martrez, Endlich, Nicole, Fleckinger, Kristina, Kotb, Ahmed M, Li, Moying, Liapis, Helen, Molnar, Jakob, Popper, Bastian, Siegerist, Florian, Thomasova, Dana   +10 more
core   +2 more sources

The emerging role of cellular senescence in renal diseases [PDF]

, 2020
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco, Chen, Rong, Francis, Heather, Glaser, Shannon, Li, Siwen, Li, Xuesen, Meng, Fanyin, Wan, Ying, Wu, Nan, Zhang, Chunmei, Zhou, Bingru, Zhou, Tianhao, Zou, Ping   +12 more
core   +1 more source

Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury.

Kidney International, 2002
BACKGROUND Traditional blood and urine markers for the diagnosis of various renal diseases are insensitive and nonspecific. Kidney Injury Molecule-1 (KIM-1) is a type 1 transmembrane protein, with an immunoglobulin and mucin domain, whose expression is ...
W. Han, V. Bailly, R. Abichandani, R. Thadhani, J. Bonventre   +4 more
semanticscholar   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Therapy with atorvastatin versus rosuvastatin reduces urinary podocytes, podocyte-associated molecules, and proximal tubule dysfunction biomarkers in patients with type 2 diabetes mellitus: a pilot study

Renal Failure, 2017
Background: Diabetic nephropathy is a severe complication of Type 2 diabetes. Tubular lesions may play an important role in its early stages. The aim of our study was to determine if atorvastatin protects the podocytes and the proximal tubule in patients
Adrian Vlad, Mihaela Vlad, Ligia Petrica, Sorin Ursoniu, Florica Gadalean, Roxana Popescu, Daliborca Vlad, Victor Dumitrascu, Gheorghe Gluhovschi, Cristina Gluhovschi, Silvia Velciov, Flaviu Bob, Petru Matusz, Alina Secara, Anca Simulescu, Dragos Catalin Jianu   +15 more
doaj   +1 more source

KAP degradation by calpain is associated with CK2 phosphorylation and provides a novel mechanism for cyclosporine A-induced proximal tubule injury. [PDF]

PLoS ONE, 2011
The use of cyclosporine A (CsA) is limited by its severe nephrotoxicity that includes reversible vasoconstrictor effects and proximal tubule cell injury, the latter associated whith chronic kidney disease progression.
Olga Tornavaca, Eduard Sarró, Gloria Pascual, Beatriz Bardaji, M Angeles Montero, M Teresa Salcedo, Maria Plana, Joan López-Hellin, Emilio Itarte, Anna Meseguer   +9 more
doaj   +1 more source

Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids

iScience, 2022
Summary: COVID-19-associated acute kidney injury (COVID-AKI) is a common complication of SARS-CoV-2 infection in hospitalized patients. The susceptibility of human kidneys to direct SARS-CoV-2 infection and modulation of the renin-angiotensin II ...
Waleed Rahmani, Hyunjae Chung, Sarthak Sinha, Maxwell P. Bui-Marinos, Rohit Arora, Arzina Jaffer, Jennifer A. Corcoran, Jeff Biernaskie, Justin Chun   +8 more
doaj   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter‐2 inhibition in experimental rats

Journal of Diabetes Investigation
Aims/Introduction While SGLT2 accounts for >90% of kidney glucose reabsorption, its pharmacological inhibition or genetic knockdown reduces glucose reabsorption by only 50%.
Ellen Wu, Sarah Macklin, Yanling Zhang, Kerri Thai, Linda Nghiem, Caterina Di Ciano‐Oliveira, Nuno Coelho, Hai Wang, Suzanne L. Advani, Jean‐François Desjardins, Darren A Yuen, Paraish Misra, Kim A. Connelly, Jens R. Nyengaard, Richard E. Gilbert   +14 more
doaj   +1 more source