Results 121 to 130 of about 99,225 (351)

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

Gambaran Histologik Ginjal Hewan Coba Postmortem [PDF]

, 2014
: Estimation of postmortem interval plays some significant roles in medicolegal investigation. This was a descriptive experimental study using one local pig as model. Samples were taken from the right and left kidneys at several time intervals: 0 minute,
Kalangi, S. J. (Sonny), Rahmadana, B. (Baldatun), Wangko, S. (Sunny)   +2 more
core  

Meta‐analysis of sotagliflozin, a dual sodium‐glucose‐cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes

ESC Heart Failure, Volume 12, Issue 2, Page 968-979, April 2025.
Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou, Panagiotis Sardellis, Josip Plascevic, Ribeya Awaes‐Mahmood, Justyna Kaczmarek, Daniel Black Boada, Rosa Thuemmler, Sam Philip   +7 more
wiley   +1 more source

Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration. [PDF]

Nat Commun, 2023
Liu C, Liu X, He Z, Zhang J, Tan X, Yang W, Zhang Y, Yu T, Liao S, Dai L, Xu Z, Li F, Huang Y, Zhao J.   +13 more
europepmc   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Etoposide Induces Necrosis Through p53-Mediated Antiapoptosis in Human Kidney Proximal Tubule Cells [PDF]

, 2015
Hyuk‐Kwon Kwon, Hyeon‐Jun Shin, Jae‐Hyeok Lee, Seol-Hee Park, Mincheol Kwon, Suresh Panneerselvam, Chan Gyu Lee, Sang Geon Kim, Jae Ho Kim, Sangdun Choi   +9 more
openalex   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Effects of proximal tubule-specific ATRAP enhancement on hypertension in a remnant kidney chronic kidney disease model of mice

Scientific Reports
Chronic kidney disease (CKD) frequently accompanies hypertension, exacerbating CKD progression in a vicious cycle. Angiotensin II type 1 receptor-associated protein (ATRAP) promotes AT1 receptor internalization to inhibit hyperactivation of its ...
Naohito Okami, Hiromichi Wakui, Shohei Tanaka, Ryu Kobayashi, Shunichiro Tsukamoto, Shinya Taguchi, Ryutaro Morita, Eisuke Kubo, Akio Yamashita, Kengo Azushima, Kouichi Tamura   +10 more
doaj   +1 more source

High-Glucose-Induced Injury to Proximal Tubules of the Renal System Is Alleviated by Netrin-1 Suppression of Akt/mTOR. [PDF]

J Diabetes Res, 2023
Liu C, Hu X, Zhao Y, Huang A, Chen J, Lu T, Wu M, Lu H.   +7 more
europepmc   +1 more source

Histopathological changes in gill, kidney and liver of an estuarine mullet, Liza parsia, induced by sublethal exposure to DDT [PDF]

, 1993
Liza parsia were exposed to sublethal (0.02 ppm) concentration of DDT for 15 days. The gill responded initially with copious secretion of mucus, oedematous separation of epithelial cells from the basement membrane and fusion of secondary gill lamellae ...
George, K.C., Lal, Shyam, Pandey, A.K., Peer Mohamed, M.   +3 more
core