Results 191 to 200 of about 99,225 (351)

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

3D vascularised proximal tubules-on-a-multiplexed chip model for enhanced cell phenotypes.

Lab Chip, 2023
Carracedo M, Robinson S, Alaei B, Clausen M, Hicks R, Belfield G, Althage M, Bak A, Lewis JA, Hansen PBL, Williams JM.   +10 more
europepmc   +1 more source

Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys. [PDF]

PLoS One, 2021
Blessing NA, Wu Z, Madhavan SM, Choy JW, Chen M, Shin MK, Hoek M, Sedor JR, O'Toole JF, Bruggeman LA.   +9 more
europepmc   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Luseogliflozin, a SGLT2 Inhibitor, Does Not Affect Glucose Uptake Kinetics in Renal Proximal Tubules of Live Mice. [PDF]

Int J Mol Sci, 2021
Zhang A, Nakano D, Kittikulsuth W, Yamashita Y, Nishiyama A.   +4 more
europepmc   +1 more source

Proximal Tubule–Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis [PDF]

, 2019
Eirini Kefaloyianni, Manikanda Raja Keerthi Raja, Julian Schumacher, Muthu Lakshmi Muthu, Vaishali Krishnadoss, Sushrut S. Waikar, Andreas Herrlich   +6 more
openalex   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules. [PDF]

Sci Rep, 2021
Khalid U, Jenkins RH, Andrews R, Pino-Chavez G, Cossins BC, Chavez R, Bowen T, Fraser DJ.   +7 more
europepmc   +1 more source

Regulation of Inwardly Rectifying K⁺ Channel in Cultured Opossum Proximal Tubule Cells by Protein Phosphatases 1 and 2A

, 2000
Manabu Kubokawa, Kazuyoshi Nakamura, Junko Hirano, Yoshichika Yoshioka, Shigeyuki Nakaya, Yoshiaki Mori, Takahiro Kubota   +6 more
openalex   +2 more sources

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

Andrology, EarlyView.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram, Murat Abay, Duygu Yaman Gram, Narin Liman, Linda Müller, Orsolya Balogh   +5 more
wiley   +1 more source