Results 91 to 100 of about 760,132 (338)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The emergence of new industries at the regional level in Spain. A proximity approach based on product-relatedness [PDF]

How do regions diversify over time? Inspired by recent studies, we argue that regions diversify into industries that make use of capabilities in which regions are specialized.
Asier Minondo, Mikel Navarro, Ron Boschma   +2 more
core  

Discovery of Radio/X-ray/Optical Resolved Supernova Remnants in the Center of the Andromeda Galaxy

, 2003
We have detected a spatially resolved supernova remnant (SNR) in the center of the Andromeda Galaxy, in radio, X-ray, and optical wavelengths. These observations provide the highest spatial resolution imaging of a radio/X-ray/optical SNR in that galaxy ...
A. K. H. Kong, B. F. Williams, Braun R., d’Odorico S., J. R. Dickel, L. O. Sjouwerman, M. R. Garcia, Magnier E. A.   +7 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Quantifying zonal interdependencies in Urban Land Valuation: A novel geospatial model of infrastructure density and road network synergies

Sustainable Futures
In the field of global urban economics, the density of transportation infrastructure and distribution of public amenities significantly impact land valuation. Nonetheless, a methodological gap persists in modelling these spatial determinants.
Shawky Mansour
doaj   +1 more source

Selection of Optimal Parameters in the Fast K-Word Proximity Search Based on Multi-component Key Indexes [PDF]

, 2021
Alexander B. Veretennikov
openalex   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Adjustment of Optimal Sports Site Selection Criteria for Elderly Using Analytical Hierarchy Process and Geographic Information System

Sālmand, 2018
Objectives Aging and its associated problems are one of the challenges in the country. This necessitates the need for proper planning during this period.
Omid Jamshidi, Morteza Doostipasha, Seyed Mohamad Hosein Razavi, Mahmood Gudarzi   +3 more
doaj  

Method of the proximity degree of complex objects evaluation on the basis of the modified index of mutual information maximization [PDF]

, 2021
Lyudmyla Yasinska-Damri
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source