Results 91 to 100 of about 180,110 (333)

A CLUE for CLUster ensembles

, 2005
Cluster ensembles are collections of individual solutions to a given clustering problem which are useful or necessary to consider in a wide range of applications.
Kurt Hornik, Hornik, Kurt
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Quantifying zonal interdependencies in Urban Land Valuation: A novel geospatial model of infrastructure density and road network synergies

Sustainable Futures
In the field of global urban economics, the density of transportation infrastructure and distribution of public amenities significantly impact land valuation. Nonetheless, a methodological gap persists in modelling these spatial determinants.
Shawky Mansour
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Adjustment of Optimal Sports Site Selection Criteria for Elderly Using Analytical Hierarchy Process and Geographic Information System

Sālmand, 2018
Objectives Aging and its associated problems are one of the challenges in the country. This necessitates the need for proper planning during this period.
Omid Jamshidi, Morteza Doostipasha, Seyed Mohamad Hosein Razavi, Mahmood Gudarzi   +3 more
doaj  

Population Proximity Layers

, 2013
This data package includes nine population proximity index layers for 2005, 2030 and 2050, for rural, urban and total populations.
Alexander, Neil S., Neil S. Alexander (3258906), William Wint (778041), Wint, William   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Analysis of flood susceptibility and zonation for risk management using frequency ratio model in District Charsadda, Pakistan

International Journal of Environment and Geoinformatics, 2018
This study focuses on the analysis of flood susceptibility and resultant zonation for risk management using frequency ratio model in District Charsadda, Pakistan.
Muhammad Farhan Ul Moazzam, Anujit Vansarochana, Atta-Ur-Rahman   +2 more
doaj   +1 more source

Unlocking Urban Accessibility: Proximity Analysis in Bangkok, Thailand’s Mega City

Sustainability
Accessibility serves as the fundamental link for mode shifts, enabling access to activity areas and facilitating connections to other forms of travel. However, navigating the transportation network in urban areas of Bangkok, Thailand, reveals persistent ...
P. Iamtrakul, A. Padon, S. Chayphong, Yoshitsugu Hayashi   +3 more
semanticscholar   +1 more source