Results 51 to 60 of about 24,122 (292)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Interpreter proxy versus healthcare interpreter for administration of patient surveys following arthroplasty: a pilot study.

BMC Medical Research Methodology, 2019
Abstract Background: Clinical quality registries and other systems that conduct routine post-discharge surveillance of patient outcomes following surgery may have difficulty surveying patients who have limited proficiency in the language of the healthcare provider.
Daniel Xue, Timothy Churches, Elizabeth Armstrong, Rajat Mittal, Justine Maree Naylor, Ian Andrew Harris   +5 more
openaire   +3 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Acknowledging the mess

Arheologia Moldovei
It is nowadays generally well acknowledged that archaeological excavation and documentation methods have a major impact on interpretations of the record. In the last decades, the effort to mitigate potential biases became increasingly visible, generally
Cristina Cordoș, Marc Händel, Mircea Anghelinu   +2 more
doaj   +1 more source

Bootstrapping a New LHC Data Transfer Ecosystem [PDF]

EPJ Web of Conferences, 2019
GridFTP transfers and the corresponding Grid Security Infrastructure (GSI)-based authentication and authorization system have been data transfer pillars of the Worldwide LHC Computing Grid (WLCG) for more than a decade.
Bockelman Brian, Hanushevsky Andrew, Keeble Oliver, Lassnig Mario, Millar Paul, Weitzel Derek, Yang Wei   +6 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

An Integrated Zooarchaeological and Micromorphological Perspective on Midden Taphonomy at Late Neolithic Çatalhöyük

Open Archaeology, 2022
The disposal of cultural material at Çatalhöyük, Turkey (7100–5950 cal BCE) has created substantial midden deposits between buildings and within abandoned houses.
Pawłowska Kamilla, Shillito Lisa-Marie
doaj   +1 more source

Land-Surface Quantitative Analysis to Investigate the Spatial Distribution of Gravitational Landforms along Rocky Coasts

Remote Sensing, 2021
The increasing availability of high-quality digital elevation models (DEMs) has been associated with a growing interest in developing quantitative analyses aimed at taking advantage of these detailed, updated, and promising digital datasets. Land-surface
Daniela Piacentini, Francesco Troiani, Davide Torre, Marco Menichetti   +3 more
doaj   +1 more source

Guidelines for the use and interpretation of palaeofire reconstructions based on various archives and proxies [PDF]

Quaternary Science Reviews, 2018
Abstract We present a comparative analysis of fire reconstructions from tree rings and from wood charcoal preserved in forest soils, peat and lake sediments. Our objective is to highlight the benefits and limits of different archives and proxies to reconstruct fire histories.
Remy, Cécile, Fouquemberg, Cécile, Asselin, Hugo, Andrieux, Benjamin, Magnan, Gabriel, Brossier, Benoît, Grondin, Pierre, Bergeron, Yves, Talon, Brigitte, Girardin, Martin, Blarquez, Olivier, Bajolle, Lisa, Ali, Adam   +12 more
openaire   +2 more sources