Results 41 to 50 of about 23,012 (263)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Genomic supremacy: the harm of conflating genetic ancestry and race

Human Genomics, 2022
Background Recent studies have reignited the tinderbox of debate surrounding the use of race and ancestry in medicine. These controversial studies have argued for a strong correlation between genetic ancestry and race, justifying continued use of genetic
Jessica P. Cerdeña, Vanessa Grubbs, Amy L. Non   +2 more
doaj   +1 more source

Guidelines for the use and interpretation of palaeofire reconstructions based on various archives and proxies [PDF]

Quaternary Science Reviews, 2018
Abstract We present a comparative analysis of fire reconstructions from tree rings and from wood charcoal preserved in forest soils, peat and lake sediments. Our objective is to highlight the benefits and limits of different archives and proxies to reconstruct fire histories.
Remy, Cécile, Fouquemberg, Cécile, Asselin, Hugo, Andrieux, Benjamin, Magnan, Gabriel, Brossier, Benoît, Grondin, Pierre, Bergeron, Yves, Talon, Brigitte, Girardin, Martin, Blarquez, Olivier, Bajolle, Lisa, Ali, Adam   +12 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Climate simulations and ice core data highlight the Holocene conundrum over tropical mountains

Communications Earth & Environment
Resolving discrepancies in long-term Holocene temperature trends between climate models and proxy records is essential to improve future climate projections.
Yuntao Bao, Zhengyu Liu, Lonnie G. Thompson, Ellen Mosley-Thompson, Lingfeng Wan, Jiuyou Lu   +5 more
doaj   +1 more source

Dating the incision of the Yangtze River gorge at the First Bend using three‐nuclide burial ages

Geophysical Research Letters, 2016
Incision of the Yangtze River gorge is widely interpreted as evidence for lower crustal flow beneath the southeast margin of the Tibetan Plateau. Previous work focused on the onset of incision, but the duration of incision remains unknown.
Devin McPhillips, Gregory D. Hoke, Jing Liu‐Zeng, Paul R. Bierman, Dylan H. Rood, Samuel Niedermann   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Coherent South American Monsoon Variability During the Last Millennium Revealed Through High‐Resolution Proxy Records

Geophysical Research Letters, 2019
The number of paleoprecipitation records from the South American Monsoon domain that cover the last millennium has increased substantially in past years.
J. L. P. S. Campos, F. W. Cruz, T. Ambrizzi, M. Deininger, M. Vuille, V. F. Novello, N. M. Strikis   +6 more
doaj   +1 more source