Results 61 to 70 of about 24,122 (292)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Support Vector Machine Based Facies Classification Using Seismic Attributes in an Oil Field of Iran [PDF]

Iranian Journal of Oil & Gas Science and Technology, 2013
Seismic facies analysis (SFA) aims to classify similar seismic traces based on amplitude, phase, frequency, and other seismic attributes. SFA has proven useful in interpreting seismic data, allowing significant information on subsurface geological ...
Majid Bagheri, Mohammad Ali Riahi
doaj   +1 more source

Joint Proxy Inversion to Improve Paleoclimate Reconstructions

, 2018
The paleoclimatologist’s toolbox is deep but filled with blunt instruments. Although we have a wide variety of proxies at our disposal, none of them provides the level of specificity or precision we desire.
Gabriel Bowen (5075396), Brenden Fisher-Femal (5155505)   +1 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Genomic supremacy: the harm of conflating genetic ancestry and race

Human Genomics, 2022
Background Recent studies have reignited the tinderbox of debate surrounding the use of race and ancestry in medicine. These controversial studies have argued for a strong correlation between genetic ancestry and race, justifying continued use of genetic
Jessica P. Cerdeña, Vanessa Grubbs, Amy L. Non   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Climate simulations and ice core data highlight the Holocene conundrum over tropical mountains

Communications Earth & Environment
Resolving discrepancies in long-term Holocene temperature trends between climate models and proxy records is essential to improve future climate projections.
Yuntao Bao, Zhengyu Liu, Lonnie G. Thompson, Ellen Mosley-Thompson, Lingfeng Wan, Jiuyou Lu   +5 more
doaj   +1 more source

Dating the incision of the Yangtze River gorge at the First Bend using three‐nuclide burial ages

Geophysical Research Letters, 2016
Incision of the Yangtze River gorge is widely interpreted as evidence for lower crustal flow beneath the southeast margin of the Tibetan Plateau. Previous work focused on the onset of incision, but the duration of incision remains unknown.
Devin McPhillips, Gregory D. Hoke, Jing Liu‐Zeng, Paul R. Bierman, Dylan H. Rood, Samuel Niedermann   +5 more
doaj   +1 more source