Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
R&D and Patenting Activity and the Propensity to Acquire in High Technology Industries [PDF]
In this paper we investigate the incidence of high technology acquisitions using a large international sample of acquisitions by public high technology firms.
Alan Hughes, Panayotis Dessyllas
core +3 more sources
Dating the incision of the Yangtze River gorge at the First Bend using three‐nuclide burial ages
Incision of the Yangtze River gorge is widely interpreted as evidence for lower crustal flow beneath the southeast margin of the Tibetan Plateau. Previous work focused on the onset of incision, but the duration of incision remains unknown.
Devin McPhillips +5 more
doaj +1 more source
On the interpretation of low-latitude hydrological proxy records based on Maunder Minimum AOGCM simulations [PDF]
An increasing number of proxy records, which are related to changes in the hydrological cycle, have been collected for climate reconstructions of the last millennium. There has been, however, little attempt to test climate models with such proxy records or to interpret proxy records using climate model simulations.
Yoshimori, Masakazu +3 more
openaire +3 more sources
The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley +1 more source
Climate simulations and ice core data highlight the Holocene conundrum over tropical mountains
Resolving discrepancies in long-term Holocene temperature trends between climate models and proxy records is essential to improve future climate projections.
Yuntao Bao +5 more
doaj +1 more source
The number of paleoprecipitation records from the South American Monsoon domain that cover the last millennium has increased substantially in past years.
J. L. P. S. Campos +6 more
doaj +1 more source
A Review of Paleo El Niño-Southern Oscillation
The Earth has seen El Niño-Southern Oscillation (ENSO)—the leading mode of interannual climate variability—for at least millennia and likely over millions of years.
Zhengyao Lu +3 more
doaj +1 more source
Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt +5 more
wiley +1 more source
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source

