Results 61 to 70 of about 55,281 (296)

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

3 PRRS-stabile sohold leverede hver 10 hold PRRS-fri smågrise [PDF]

, 2014
I tre besætninger var det muligt at producere 10 PRRS-fri hold af smågrise i hver besætning over tid, selvom soholdet var PRRS-positivt. Dette var muligt på trods af forskelle i produktionssystemer, karantænebrug og PRRS-vaccinationsstrategier.I ...
Kristensen, Charlotte Sonne, Larsen, Lars Erik, Hjulsager, Charlotte Kristiane   +2 more
core  

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases

Cell & Bioscience, 2022
Dysregulation of auto-reactive T cells and autoantibody-producing B cells and excessive inflammation are responsible for the occurrence and development of autoimmune diseases. The suppression of autoreactive T cell activation and autoantibody production,
Jun Liu, Hui Zhang, Yanhong Su, Baojun Zhang   +3 more
doaj   +1 more source

Economic Analysis of PRRS Virus Elimination from a Herd [PDF]

, 2012
A net present value (NPV) analysis was performed to evaluate PRRS virus elimination from individual herds. The NPV analysis conducted for this study is the first analysis of which the authors are aware that accounts for the more severe negative ...
Mowrer, Christine, Holtkamp, Derald, Zimmerman, Jeffrey, Yoder, Tiffany, Kliebenstein, James, Rotto, Hans, Wang, Chong, Yeske, Paul, Neumann, Eric, Haley, Charles   +9 more
core   +1 more source

Continuous‐Flow Microfluidic Synthesis Enhances C2+ Selectivity for Cu2O Catalysts

Advanced Science, EarlyView.
Microfluidic devices are used to prepare Cu2O nanoparticles under laminar flow conditions, which exhibit enhanced selectivity in the CO2‐to‐C2+ reaction due to their nanoporosity and high defect concentration. Cu2O prepared using standard solution methods displays decreased CO2‐to‐C2+ selectivity due to the absence of similar properties. Altogether, we
Carlota Casas, Anh Tuan Ngo, João Pedro Vale, Ona Falcó, Gerard Martí, Mohamed Amazian, Júlia Mayans, Sònia Estradé, Marcos Gil‐Sepulcre, Teresa Andreu, Francesca Peiró, Tiago Sotto Mayor, Lluís Yedra, Jordi García‐Antón, Josep Puigmartí‐Luis, Xavier Sala, Roc Matheu   +16 more
wiley   +1 more source

Simultaneous Detection and Differentiation of Highly Virulent and Classical Chinese-Type Isolation of PRRSV by Real-Time RT-PCR

Journal of Immunology Research, 2014
Porcine reproductive and respiratory syndrome (PRRS) is a leading disease in pig industry worldwide and can result in serious economic losses each year.
Shuqi Xiao, Yaosheng Chen, Liangliang Wang, Jintao Gao, Delin Mo, Zuyong He, Xiaohong Liu   +6 more
doaj   +1 more source

Genetic analysis of reproductive performance in sows during porcine reproductive and respiratory syndrome (PRRS) and porcine epidemic diarrhea (PED) outbreaks

Journal of Animal Science and Biotechnology, 2019
Background Porcine reproductive and respiratory syndrome (PRRS) is one of the most infectious swine diseases in the world, resulting in over 600 million dollars of economic loss in the USA alone.
Cassandra L. Scanlan, Austin M. Putz, Kent A. Gray, Nick V. L. Serão   +3 more
doaj   +1 more source

Episode 37: Infectivity of PRRS virus variants

, 2023
Runtime 23:48In the podcast Swine Extension Educator Sarah Schieck Boelke speaks with PhD student Marcello Melini about his research on the infectivity of PRRS virus variant 1-4-4 as it comparies to other PRRS virus variants.Schieck Boelke, Sarah; Melini,
Melini, Marcello, Schieck Boelke, Sarah
core  

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source