Results 141 to 150 of about 31,239 (262)

Harnessing machine learning and optimization for informed chemical engineering decisions: A styrene reactor analysis

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
This study shows that integrating multiple machine learning models with optimization and decision‐making improves chemical process design, and that a consensus‐based strategy across models provides more robust and reliable operating recommendations than any single model, especially under limited or noisy data conditions.
Farough Agin   +2 more
wiley   +1 more source

Hybrid framework for on‐the‐fly diagnosis of energy inefficiency in multi‐unit processes based on data‐driven and knowledge‐based integration

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Abstract Pinpointing the true roots of energy waste in large, multi‐unit industrial systems is notoriously difficult: the data are high‐dimensional, and process units are tightly interlinked. This paper presents a powerful hybrid diagnostic framework that integrates explainable AI (XAI), Granger causality (GC), and fault tree analysis (FTA).
Mohamed El Koujok   +2 more
wiley   +1 more source

Dihydropyrimidine Dehydrogenase Genotype–Phenotype Correlations in Plasma and Peripheral Blood Mononuclear Cells

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The chemotherapeutic 5‐fluorouracil (5‐FU) is commonly used to treat solid tumors, especially colorectal cancer. Deleterious variants in DPYD, which encodes dihydropyrimidine dehydrogenase (DPD), are strongly associated with severe and potentially lethal 5‐FU toxicity.
Brianna M. Bembenek   +4 more
wiley   +1 more source

Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report

open access: yesEpileptic Disorders, EarlyView.
Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori   +4 more
wiley   +1 more source

Lean Unet: a compact model for image segmentation. [PDF]

open access: yesInt J Comput Assist Radiol Surg
Hassler T   +4 more
europepmc   +1 more source

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS. Methods We identified participants with highest (n = 59) versus lowest (n 
Sophie von Brauchitsch   +27 more
wiley   +1 more source

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