Results 51 to 60 of about 77,820 (264)

Dupilumab‐Related Adverse Events and Intolerance in Aspirin‐Exacerbated Respiratory Disease Patients

International Forum of Allergy &Rhinology, EarlyView.
Lancelot P. Herpin, Randy Bach, Ricardo Bruneto, Kerol A. Faltas, Michael A. Kohanski, James N. Palmer, Nithin D. Adappa, Jennifer E. Douglas, John V. Bosso   +8 more
wiley   +1 more source

Delayed diagnosis of 3β‐HSD7 deficiency in adolescence: Two case reports and review of the literature

JPGN Reports, EarlyView.
ABSTRACT Congenital bile acid synthesis defects (BASD), the most common of which is 3β‐hydroxy‐Δ5‐C27‐steroid dehydrogenase oxidoreductase (3β‐HSD7) deficiency, are a rare cause of fat‐soluble vitamin malabsorption. We describe a 14‐year‐old girl who presented at 14 months with a left distal femur fracture and failure to thrive.
Samantha Pendleton, Mojdeh Mostafavi, Jamie Mathew, Kayla Ganzburg, Barry Hirsch, Nadia Ovchinsky, Wael Sayej   +6 more
wiley   +1 more source

Clinically Meaningful Improvements in Quality of Life, Including Sleep, With Two‐Week and Monthly Dosed Rademikibart: A Phase 2 Randomized Trial in Adults With Moderate‐to‐Severe Atopic Dermatitis

JEADV Clinical Practice, EarlyView.
Rademikibart, a potent IL‐4Rα‐targeting antibody, achieved its primary endpoint as a treatment for adults with moderate‐to‐severe atopic dermatitis (AD) in the CBP‐201‐WW001 Phase 2 trial. There is a need for AD treatment options with convenient dosing intervals.
Jonathan I. Silverberg, Emma Guttman‐Yassky, Raúl Collazo   +2 more
wiley   +1 more source

Criteria Suggestive of Psychological Components of Itch and Soma­toform Itch: Study of a Large Sample of Patients with Chronic Pruritus

Acta Dermato-Venereologica, 2020
While psychological factors are relevant in many patients with chronic pruritus, not all patients can be offered psychologic, psychosomatic or psychiatric consultation.
Gudrun Schneider, Anna Grebe, Philipp Bruland, Gereon Heuft, Sonja Ständer   +4 more
doaj   +1 more source

Prevalence and Burden of Somatic Symptom Disorder in Atopic Dermatitis and Chronic Pruritus—The Persistent Somatic Symptoms Across Diseases: Pruritus (SOMA.PRU) Study

JEADV Clinical Practice, EarlyView.
In adults with atopic dermatitis and chronic pruritus, the mental comorbidity of Somatic Symptom Disorder is associated with higher average and worst pruritus intensity, higher psychological distress and lower quality of life. Additionally, there were nonsignificant changes in cutaneous nerve fiber densities in skin biopsies.
Stefan M. Kahnert, Ansgar Koechel, Gina L. Frank, Svenja Royeck, Claudia Zeidler, Felix Witte, Christian Mess, Konstantin Agelopoulos, Volker Huck, Bernd Löwe, Rupert Conrad, Gudrun Schneider, Stefan W. Schneider, Sonja Ständer   +13 more
wiley   +1 more source

First Report of Homozygous COL7A1 c.5756delG Mutation Causing Recessive Dystrophic Epidermolysis Bullosa in a Non‐Consanguineous Japanese Family

JEADV Clinical Practice, EarlyView.
ABSTRACT Severe recessive dystrophic epidermolysis bullosa (RDEB) is usually caused by biallelic loss‐of‐function mutations in COL7A1. While the c.5756delG variant has been previously reported in heterozygous form, its clinical impact in homozygosity has not been described.
Nozomi Kohama, Sayaka Yamaguchi, Teruki Yanagi, Yumi Akamine, Kimiko Nonaka, Daisuke Utsumi, Kenzo Takahashi   +6 more
wiley   +1 more source

Self-reported generalised pruritus among community-dwelling older adults in Malaysia

BMC Geriatrics, 2020
Background The ageing skin is more susceptible to pruritic dermatoses, which are associated with adverse psychosocial effects and reduced quality of life among older adults.
Shin Shen Yong, Zhenli Kwan, Chin Chwen Ch’ng, Adrian Sze Wai Yong, Leng Leng Tan, Winn Hui Han, Shahrul Bahyah Kamaruzzaman, Ai-Vyrn Chin, Maw Pin Tan   +8 more
doaj   +1 more source

Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride

Scientific Reports, 2021
Pruritus is known to be a common complication in hepatitis patients, but the exact frequency and degree are not fully elucidated. Thus, we evaluated pruritus of 450 patients with chronic liver disease at our hospital.
Shuhei Yoshikawa, Takeharu Asano, Mina Morino, Keita Matsumoto, Hitomi Kashima, Yudai Koito, Takaya Miura, Yuko Takahashi, Rumiko Tsuboi, Takehiro Ishii, Haruka Otake, Junichi Fujiwara, Masanari Sekine, Takeshi Uehara, Kazuhito Yuhashi, Satohiro Matsumoto, Shinichi Asabe, Hiroyuki Miyatani, Hirosato Mashima   +18 more
doaj   +1 more source

A Case of Pembrolizumab‐Induced Pityriasis Lichenoides‐Like Eruption Treated Successfully With Dupilumab

JEADV Clinical Practice, EarlyView.
ABSTRACT Immune‐checkpoint inhibitors (ICIs) have revolutionised melanoma treatment but can often cause severe and long‐standing cutaneous immune‐related adverse events (cirAEs). We report a case of refractory pembrolizumab‐induced pityriasis lichenoides (PL)‐like eruption successfully treated with dupilumab, leading to rapid and sustained remission ...
Evangelos Christou, Sharon Edwards, Andrew Affleck   +2 more
wiley   +1 more source

Evidences for gestures associated with pruritus in very young infants: a pilot study

Scientific Reports
The anatomical and functional basis for pruritus is present from birth. However, pruritus in this population is largely underestimated. The aim of this study was to analyze behaviors potentially associated with pruritus in infants under 6 months ...
Adrien Boyard, Camille Cosnard, David Simon, Camille Le Pors, Claire Abasq-Thomas, Marine Grandgeorge, Laurent Misery, Séverine Henry, Jean-Michel Roué   +8 more
doaj   +1 more source