Results 171 to 180 of about 232,710 (307)

Maternal and infant gut microbiome

open access: yesiMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang   +25 more
wiley   +1 more source

Past, Present, and Future of Telerobotic Surgery in Urology: From Technological Breakthroughs to Global Adoption

open access: yesiNew Medicine, EarlyView.
The Development and Future of Remote Robots in Urology. ABSTRACT Ever since the “Lindbergh Operation” in 2001, the field of remote robotic surgery has transformed from theoretical study toward practical clinical integration on a global scale. Considering the millimeter‐level precision that is required in the field of urological oncology, remote ...
Cheng Yang   +6 more
wiley   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

open access: yesInterdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang   +11 more
wiley   +1 more source

A Personal Perspective on Metalloprotein Structure and the Future of Macromolecular X‐Ray Crystallography

open access: yesJournal of the Chinese Chemical Society, EarlyView.
While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley   +1 more source

Clinical Rationale of Dual‐Parameter Tumor Markers Reporting Without Reliance on Normal Reference Ranges

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
We recommend the current practice of tumor marker reporting to upgrade to two‐figure format to include a specific growth rate in parentheses. This can be of great clinical importance, especially in the subnormal range. ABSTRACT Introduction This review offers clinicians a novel view of tumor markers (TM).
Jurate Civinskaite   +5 more
wiley   +1 more source

Do prostate cancer risk models improve the predictive accuracy of PSA screening? A meta-analysis.

open access: yesAnnals of Oncology, 2015
K. Louie   +6 more
semanticscholar   +1 more source

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