Results 191 to 200 of about 191,374 (287)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models. [PDF]

Stat Med
Owens L, Rizopoulos D, Fainberg J, Carlsson S, Liso N, McBride S, Laudone V, Etzioni R, Taylor JMG.   +8 more
europepmc   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Association of Early-Life Exposures With Later Diagnosis of Spondyloarthritis: A Population-Based Case-Control Study. [PDF]

J Rheumatol
Altaffer AL, Weisman MH, Kaplan RM, Horváth-Puhó E, Sørensen HT, Weiss PF.   +5 more
europepmc   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Genetic Evidence for Causal Effects of Domain-Specific Physical Activity and Sedentary Behavior on Osteoporosis and Inflammatory Arthritis: A Bidirectional Mendelian Randomization Study. [PDF]

Genes (Basel)
Sun T, Zhang F, Liu C, Huang J.
europepmc   +1 more source

A Personal Perspective on Metalloprotein Structure and the Future of Macromolecular X‐Ray Crystallography

Journal of the Chinese Chemical Society, EarlyView.
While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley   +1 more source

Psoriasis patients with psoriatic arthritis demonstrate a reduced regulatory capacity for neutrophil elastase. [PDF]

Rheumatology (Oxford)
Macleod T, Dubash SR, Hyde I, Michelena X, Berekmeri A, Helliwell PS, Kingsbury SR, Laws P, Mankia K, Stacey M, Marzo-Ortega H, Wittmann M.   +11 more
europepmc   +1 more source

Clinical Rationale of Dual‐Parameter Tumor Markers Reporting Without Reliance on Normal Reference Ranges

Journal of Clinical Laboratory Analysis, EarlyView.
We recommend the current practice of tumor marker reporting to upgrade to two‐figure format to include a specific growth rate in parentheses. This can be of great clinical importance, especially in the subnormal range. ABSTRACT Introduction This review offers clinicians a novel view of tumor markers (TM).
Jurate Civinskaite, Daiva Gudaviciene, Gintaras Zaleskis, Aleksandras Petrauskas, Dainius Characiejus, Tatjana Ivaskiene   +5 more
wiley   +1 more source

Preoperative Magnetic Resonance Imaging Findings of the Transition Zone Predict Incidental Prostate Cancer in HoLEP. [PDF]

Cancer Diagn Progn
Ito T, Hisamatsu Y, Mizutani S, Kodama T, Watanabe S, Amano H, Inamoto T.   +6 more
europepmc   +1 more source