Results 151 to 160 of about 12,045 (211)

Bipolar Androgen Therapy as a Potential Mechanistic Bridge to Enhance PARP Inhibitor Efficacy in Prostate Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Prostate cancer remains a leading cause of cancer‐related mortality, largely driven by progression to metastatic castration‐resistant prostate cancer (mCRPC). Although poly(ADP‐ribose) polymerase inhibitors (PARPis) have improved outcomes in patients with homologous recombination repair (HRR) alterations, particularly in BRCA2‐mutated disease,
Jhen‐Hao Jhan, Jiun‐Hung Geng, Hung‐Lung Ke, Shu‐Pin Huang, Li Jia   +4 more
wiley   +1 more source

Tibia‐first, gap‐balanced patient‐specific alignment in total knee arthroplasty achieves better ligament balance than mechanical, kinematic and functional alignment strategies

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This study evaluates four different alignment techniques to assess total knee arthroplasty (TKA) balance. Methods A prospective cohort of 400 patients undergoing primary robotic‐assisted cruciate‐retaining TKA was analysed. The Velys TKA robotic system collects a balance curve that enables the surgeon to intraoperatively analyse the ...
Guido Wierer, Mark Clatworthy
wiley   +1 more source

Mixed Litter Decomposition Drives Functional Gene Rearrangement in the Microbial Carbon Cycle

Land Degradation &Development, EarlyView.
ABSTRACT Understanding how mixed‐species litter decomposition regulates microbial communities and carbon cycling is vital for guiding ecosystem restoration and climate change mitigation, as it is a key process for nutrient cycling and carbon sequestration. A 15‐month field experiment compared single‐species (Pinus sylvestris var.
Jiaying Liu, Changjun Ding, Weixi Zhang, Xiaohua Su, Yawei Wei, Siqi Wu, Wenxu Zhu   +6 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley   +1 more source

Staged Bilateral Magnetic Resonance‐Guided Focused Ultrasound for Treating Essential Tremor: Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Unilateral magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy reduces tremor in essential tremor, yet disability often persists on the untreated side. The added benefit and safety of a staged contralateral lesion remain uncertain.
Nima Norbu Sherpa, Andrea Gonzalez Lezana, Gabriela Prilip, Kenji Fukutome, Nathan J. Pertsch, Ruth Reeve, Nadège Bault, Elsa Fouragnan   +7 more
wiley   +1 more source

The Conventional Cost‐Effectiveness and Distributional Cost‐Effectiveness of Semaglutide for Obesity Treatment

Obesity, EarlyView.
ABSTRACT Objective This study aimed to evaluate the conventional and distributional cost‐effectiveness of semaglutide, laparoscopic sleeve gastrectomy (LSG), and a “do nothing” option in Black and White racial subgroups. Methods A Markov simulation model was developed from a healthcare perspective over a 25‐year time horizon for Black and White adults,
Neeti S. Kulkarni, David Hutton, Corwin Rhyan, Jeffrey S. McCullough, Michaela Greenlee, Ankur Pandya   +5 more
wiley   +1 more source

Polypropylene Nonwoven Fabric Filters Containing Graphene Oxide: A Streamlined Approach to Enhance Ultrafine Particulate Matter Removal

Polymer Engineering &Science, EarlyView.
A simple graphene oxide coating strategy enhanced the ultrafine particulate matter (PM0.1) filtration performance of polypropylene nonwoven filters. The oxygen‐containing functional groups of graphene oxide improved particle capture while preserving low pressure drop and high air permeability.
Manoel Messias Coutinho Meira, Amanda Araújo da Silva, Bruno de Araújo Lima, Monica Lopes Aguiar, Joyce Cristale, Diego Stéfani Teodoro Martinez, Marcos Vinicius Lorevice, Simone Andréa Pozza   +7 more
wiley   +1 more source

Exploratory Analysis of Peri‐Prostatic Adipose Tissue Radiomics Features and Their Potential to Predict Prostate Cancer Diagnosis: Results From a UK Biobank Study

The Prostate, EarlyView.
ABSTRACT Introduction This paper reports the development and application of an artificial intelligence (AI)–led approach to large volume MRI data curation and image segmentation of periprostatic adipose tissue (PPAT) in prostate cancer (PCa)–free men from the UK Biobank. We report how PPAT was defined, radiomics features of PPAT extracted, and explored
Angela O'Neill, Ryan O'Keeffe, Sarah Winter, Jade Dorrian, Tom R. Gaunt, Vilmundur Guönason, Ruth C. Travis, Richard M. Martin, Emma H. Allott, Michelle Leech   +9 more
wiley   +1 more source