Results 121 to 130 of about 145,081 (341)

Live Imaging of Endogenous PSD-95 Using ENABLED: A Conditional Strategy to Fluorescently Label Endogenous Proteins

Journal of Neuroscience, 2014
Stoichiometric labeling of endogenous synaptic proteins for high-contrast live-cell imaging in brain tissue remains challenging. Here, we describe a conditional mouse genetic strategy termed endogenous labeling via exon duplication (ENABLED), which can ...
Dale A. Fortin, S. Tillo, Guang Yang, J. Rah, Joshua B. Melander, S. Bai, Omar Soler-Cedeño, Mao-Zhen Qin, B. Zemelman, Cai-Ying Guo, Tian-Yi Mao, H. Zhong   +11 more
semanticscholar   +1 more source

Osmium Nanoparticle Anchoring on CoFe Layered Double Hydroxides Enables High‐Valent Species Stabilization and Efficient Seawater Oxygen Evolution

Advanced Science, EarlyView.
Osmium nanoparticles anchored on CoFe layered double hydroxide (Os/CoFe LDH) stabilize high‐valent Co/Fe species and modulate the interfacial water configuration via surface engineering. This work presents a facile surface engineering strategy for constructing efficient and durable OER electrocatalysts for alkaline seawater, and expands the ...
Xindong She, Guosheng Zhou, Kanghua Miao, Junjie Gong, Mingzhe Jiang, Xueting Zhu, Zhenzhen Wang, Shijie Shen, Wenwu Zhong   +8 more
wiley   +1 more source

I servizi di pagamento [PDF]

IANUS Diritto e Finanza, 2012
Il contributo ricostruisce criticamente la disciplina dei servizi di pagamento nei suoi profili oggettivi e soggettivi, avendo riguardo alla direttiva 2007/64 CE, al d.lgs. n. 11 del 2010 ed alla disciplina della Banca d’Italia.
Vittorio Santoro
doaj  

Improved Speech Enhancement Considering Speech PSD Uncertainty

, 2022
Speech enhancement based on statistical models has been studied for several decades. Recently, the speech enhancement adopting a speech power spectral density (PSD) uncertainty model has been proposed. This approach distinguishes the true speech PSD from
Kim, M., Shin, Jong Won
core   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Motor Impairments, Striatal Degeneration, and Altered Dopamine-Glutamate Interplay in Mice Lacking PSD-95

Journal of neurogenetics, 2014
Excessive activation of the N-methyl-d-aspartate (NMDA) receptor and the neurotransmitter dopamine (DA) mediate neurotoxicity and neurodegeneration under many neurological conditions, including Huntington's disease (HD), an autosomal dominant ...
Jingping Zhang, Taixiang Saur, Angela N. Duke, S. Grant, D. Platt, J. Rowlett, O. Isacson, Wei-Dong Yao   +7 more
semanticscholar   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation and mGluR signaling

Molecules and Cells, 2011
Summary The molecular mechanism how RISC and microRNAs selectively and reversibly regulate mRNA translation in response to receptor signaling is unknown but could provide a means for temporal and spatial control of translation. Here we show that miR-125a
Ravi S. Muddashetty, Vijayalaxmi C. Nalavadi, Christina Gross, Xiaodi Yao, L. Xing, O. Laur, S. Warren, G. Bassell   +7 more
semanticscholar   +1 more source

Dual Randomness From Spatial and Temporal Variations in Stochastic Zinc Gallate Nanoclusters for PUF and TRNG Co‐Driven Image Generation

Advanced Science, EarlyView.
A dual‐randomness hardware platform is demonstrated by integrating PUF and TRNG functionalities into mixed‐ZGO nanoclusters. By leveraging spatial and temporal stochasticity, the mixed‐ZGO NCs device enables both unique identification and random signal generation.
Seungme Kang, Wangmyung Choi, Jueun Lee, Yeong Kwon Kim, Byung Chul Jang, Wonjun Shin, Hocheon Yoo   +6 more
wiley   +1 more source

Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

Cell, 2012
Summary The activity-dependent transcription factor, Myocyte Enhancer Factor-2 (MEF2), induces excitatory synapse elimination in mouse neurons which requires Fragile X Mental Retardation Protein (FMRP), an RNA binding protein implicated in human ...
Nien-Pei Tsai, Julie R. Wilkerson, Weirui Guo, M. A. Maksimova, G. DeMartino, C. W. Cowan, K. Huber   +6 more
semanticscholar   +1 more source