A Winogradsky-based culture system shows an association between microbial fermentation and cystic fibrosis exacerbation. [PDF]
There is a poor understanding of how the physiology of polymicrobial communities in cystic fibrosis (CF) lungs contributes to pulmonary exacerbations and lung function decline.
Bailey, Barbara+9 more
core +1 more source
Computational and AI‐Driven Design of Hydrogels for Bioelectronic Applications
This review highlights the role of AI in advancing hydrogel design for bioelectronics, exploring natural, and synthetic gels tailored for applications like wound healing, biosensing, and tissue engineering. It emphasizes the synergy between hydrogels, electronics, and AI in creating responsive, multifunctional systems, showcasing recent innovations ...
Rebekah Finster+2 more
wiley +1 more source
This meta‐analysis compared olanexidine gluconate (OLG) with conventional antiseptics on surgical site infections (SSIs) in gastroenterological surgery. OLG significantly reduced overall SSIs without statistical heterogeneity. Abstract Aim To compare the preventative effect of the new antiseptic olanexidine gluconate (OLG) with conventional antiseptics
Akihisa Matsuda+4 more
wiley +1 more source
Saarvienin A—A Novel Glycopeptide with Potent Activity against Drug‐Resistant Bacteria
A structurally distinct glycopeptide, saarvienin A, represents a new family of glycopeptide antibiotics consisting of five sugar/aminosugar units connected to a halogenated peptide core. Saarvienin A overcomes vancomycin resistance and shows strong activity against drug‐resistant Gram‐positive bacteria, in particular, high‐priority pathogens such as ...
Amninder Kaur+7 more
wiley +2 more sources
Hydrogel‐Based Smart Materials for Wound Healing and Sensing
The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong+11 more
wiley +1 more source
Antimicrobial Peptide‐Peptoid Macrocycles from the Polymyxin B2 Chemical Space
We optimized mixed peptide‐peptoid sequences for molecular similarity to the macrocyclic lipopeptide antibiotic polymyxin B2 (PMB2) using a genetic algorithm. Synthesis and testing of top‐scoring compounds allowed us to identify new macrocycles with similar antimicrobial activity and reduced toxicity compared to PMB2.
Etienne Bonvin+7 more
wiley +2 more sources
Two novel XOFs based on [N···Br+···N] interactions were constructed. The XOFs(Br) deliver superior antibacterial properties compared with XOFs(I), due to a greater oxidation capability. Moreover, XOF(Br)‐TPPA, exhibiting greater hydrophilicity, shows superior antibacterial properties relative to XOF(Br)‐TPPE, which is weakly hydrophilic.
Zhennan Tian+13 more
wiley +1 more source
Multi‐Module Micro/Nanorobots for Biomedical and Environmental Remediation Applications
Multi‐module microrobots (MNRs) have overcome the limitations of single‐module systems by integrating components such as propeller, actuator, manipulator, and imaging modalities. They show promise in biomedical applications, such as targeted drug delivery and tissue repair, as well as in environmental remediation, including pollutant removal.
Bairong Zhu+4 more
wiley +1 more source
Antibacterial Siderophores of Pandoraea Pathogens and Their Impact on the Diseased Lung Microbiota
Genome mining of environmental and pathogenic Pandoraea species identified a conserved NRPS gene cluster and led to the discovery of novel siderophores, pandorabactins, which exert their antibacterial activity by depleting iron from competitors. Bioinformatic analysis of sputum from cystic fibrosis patients coupled with bioassays indicates that ...
Elena Herzog+8 more
wiley +2 more sources
Results of A Local Combination Therapy Antibiogram For \u3cem\u3ePseudomonas Aeruginosa\u3c/em\u3e Isolates: Is Double Worth The Trouble? [PDF]
Purpose: To determine the frequency at which fluoroquinolones and aminoglycosides demonstrate in vitro activity against non-urinary, non-skin/skin structure Pseudomonas aeruginosa isolates exhibiting decreased susceptibilities to one or more β-lactam ...
Davis, Jim+4 more
core +1 more source