Results 1 to 10 of about 5,165 (174)

ADP-ribosyl transferase activity and gamma radiation cytotoxicity of Pseudomonas aeruginosa exotoxin A. [PDF]

AMB Express, 2021
This work explores the ADP-ribosyltransferase activity of Pseudomonas (P.) aeruginosa exotoxin A using the guanyl hydrazone derivative, nitrobenzylidine aminoguanidine (NBAG) and the impact of gamma radiation on its efficacy.
Morgan RN, Saleh SE, Aboshanab KM, Farrag HA.   +3 more
europepmc   +2 more sources

A pipeline to evaluate inhibitors of the Pseudomonas aeruginosa exotoxin U. [PDF]

Biochem J, 2021
Pseudomonas aeruginosa has recently been highlighted by the World Health Organisation (WHO) as a major threat with high priority for the development of new therapies. In severe P. aeruginosa infections, the phospholipase activity of the type 3 secretion system toxin, ExoU, induces lysis of target host cells and results in the poorest clinical outcomes.
Foulkes DM, McLean K, Zheng Y, Sarsby J, Haneef AS, Fernig DG, Winstanley C, Berry N, Kaye SB.   +8 more
europepmc   +4 more sources

A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. [PDF]

PLoS One, 2016
Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease.
Ferguson TE, Reihill JA, Walker B, Hamilton RA, Martin SL.   +4 more
europepmc   +2 more sources

Pseudomonas aeruginosa exotoxin A as a novel allergen induced Non-T_H2 inflammation in a murine model of steroid-insensitive asthma. [PDF]

Heliyon
Background: Despite the immediate in vivo occurrence of anaphylactic and allergic reactions following treatment with Pseudomonas aeruginosa exotoxin A (PEA)-based immunotoxins, the immunological role of PEA in asthma pathogenesis remains unclear ...
Xie H, Li L, Guo Y, Zhou L, Ma L, He A, Lai H, He Y, Liu Y, Chen H, Luo L, Huang Y, Sha X, Zhang H, Yan J, Zhang Q, Tao A.   +16 more
europepmc   +2 more sources

Pseudomonas Exotoxin A: optimized by evolution for effective killing

Frontiers in Microbiology, 2015
Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE.
Philipp Wolf
exaly   +3 more sources

Preparation and evaluation of the exotoxin A nano-gold conjugate as a vaccine candidate for Pseudomonas aeruginosa infections [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Pseudomonas aeruginosa is an opportunistic pathogen that is an important cause of nosocomial infections. This bacterium produces various virulence factors, among which exotoxin A is significantly involved in mortality and morbidity. In this
Masoumeh Abbasi, Asghar Tanomand, Farshid Kafilzadeh, Samaneh Zolghadri, Hasan Hosainzadegan   +4 more
doaj   +1 more source

PCR based identification of exotoxin A-producing Pseudomonas aeroginosa isolated from burn wound infection [PDF]

Trends in Pharmaceutical Sciences, 2022
Exotoxin A (exoA) is a major pathogenic factor in Pseudomonas aeruginosa. This non-fermenting gram-negative bacillus causes a wide range of infections. P. aeruginosa is a major cause of hospital-acquired infections.
Gholamreza Morshedi, Vahid Ghanbarinejad, Mina Zareei, Abazar Poornajaf, Hossein Hassanian-Moghaddam, Vahid Hadi, Abbas Isvand, Mohammad reza Saadati, Homayoun Maleki, Majid Keshavarzi   +9 more
doaj   +1 more source

ISOLATION AND PURIFICATION OF ANTICANCER PROTEIN EXOTXIN A FROM Pseudomonas aeruginosa

The Iraqi Journal of Agricultural science, 2022
Toxins produced from bacteria constitute promising antitumor agents in treating different cancer types. Exotoxin A from Pseudomonas aeruginosa is the highly toxic virulence component that bind to specific cell receptors.
L. Q. Jawad, H. A. R. R. Rasheed
doaj   +1 more source

Cloning, Expression and Evaluation of Pseudomonas Aeruginosa Exotoxin A

مجله دانشکده پزشکی اصفهان, 2014
Background: Nowadays, in many studies related to the treatment of various cancers, toxic compounds are targeted against cancer cells. One of the most effective compounds is Pseudomonas exotoxin A. The purpose of this study was to investigate the expression, purification, and in-vitro evaluation of a short form of the toxin in a prokaryotic expression ...
Jahangir Langari, Majid Golkar, Hossein Khanahmad, Morteza Karimipoor, Roghayeh Arezumand, Ramazan Behzadi, Reza Ahangari-Cohan   +6 more
openaire   +2 more sources

LINK BETWEEN SOME VIRULNCE FACTORS GENES AND ANTIBACTERIAL RESISTANCE OF PSEUDOMONAS AERUGINOSA

The Iraqi Journal of Agricultural science, 2022
The research was aimed to demonstrate the frequency of virulence factors genes (exoenzyme S and exotoxin A) and to express their relationship to antibacterial resistance among Pseudomonas aeruginosa isolated from patients suffering from otitis externa ...
Aida H. Ibrahim
doaj   +1 more source