Results 11 to 20 of about 5,165 (174)
Detection of Toxin Genes and Biofilm Formation of <i>Pseudomonas aeruginosa</i> Associated With Respiratory Tract Infections in Riyadh, Saudi Arabia. [PDF]
Int J MicrobiolPseudomonas aeruginosa infections associated with the respiratory system may cause significant damage to the lung tissue, which may lead to death. This study aimed to detect the presence of toxin genes, antibiotic resistance, and biofilm formation in P. aeruginosa isolates associated with respiratory tract infections. A total of 60 P.
Aljaaidi R +6 more
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Structural Characterization and Functional Annotation of Hypothetical Proteins in the Multidrug-Resistant Strains of <i>Pseudomonas aeruginosa</i>. [PDF]
Biomed Res IntIntroduction Pseudomonas aeruginosa is a leading cause of severe nosocomial infections worldwide. This opportunistic pathogen is associated with increased morbidity and mortality rates due to its high levels of antibiotic resistance. The identification of novel therapeutic targets is therefore a pressing global health priority.
Khoonsari FN, Zafari Z.
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BMC Infectious Diseases, 2021 Background Pseudomonas aeruginosa is the leading cause of nosocomial infections, especially in people with a compromised immune system. Targeting virulence factors by neutralizing antibodies is a novel paradigm for the treatment of antibiotic-resistant ...
Zahra Shadman +6 more
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Rhus coriaria extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Numerous studies have confirmed sumac’s ability to inhibit pathogens and even eradicate chronic drug-resistant infections. Current research was conducted to demonstrate the action of various sumac extracts at sub-inhibitory concentrations ...
Akhter Ahmed +2 more
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Exotoxin production by clinical isolates of pseudomonas aeruginosa [PDF]
Infection and Immunity, 1977 Seventy-five consecutive clinical Pseudomonas aeruginosa isolates were tested for in vitro exotoxin production. Exotoxin was demonstrated in culture filtrates biologically, by its ability to produce characteristic dermonecrotic lesions in guinea pigs, and seriologically, by counterimmunoelectrophoresis (CIE) with rabbit antiserum elicited with purified
M, Pollack, N S, Taylor, L T, Callahan
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Toxicity of Pseudomonas aeruginosa exotoxin A for human macrophages [PDF]
Infection and Immunity, 1978 Pseudomonas aeruginosa exotoxin A was toxi in vitro for human peripheral blood macrophages. Cytotoxicity, manifested by morphological evidence of cell death and inhibition of [3H]thymidine uptake, followed exposure to as little as 10 ng of exotoxin per ml for 1 h.
M, Pollack, S E, Anderson
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Purification of Pseudomonas aeruginosa exotoxin by affinity chromatography [PDF]
Infection and Immunity, 1978 Pseudomonas aeruginosa exotoxin A was purified by affinity chromatography from culture supernatants by elution of toxin from antitoxin immunoglobulin G-Sepharose 4B with 3 M NaSCN. The purity, toxicity, and enzymatic activity of exotoxin obtained were comparable to those of toxin purified by previously reported multiple-step procedures.
N S, Taylor, M, Pollack
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Structure-activity relationships of an exotoxin of Pseudomonas aeruginosa [PDF]
Infection and Immunity, 1977 The relation of the structure of Pseudomonas aeruginosa exotoxin A (PA toxin) to its enzymatic activity (adenosine 5'-diphosphate-ribosyl transferase) in vitro and to its toxicity in vivo was examined. PA toxin is produced as a single polypeptide chain with a molecular weight of about 71,500.
M L, Vasil, D, Kabat, B H, Iglewski
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Transcription and Expression of the Exotoxin A Gene of Pseudomonas aeruginosa [PDF]
Microbiology, 1987 The exotoxin A genes from Pseudomonas aeruginosa strains PA103 and PAO1 have been independently cloned in a pUC9-derived plasmid. In a non-toxigenic mutant of PAO1 as host, the cloned genes directed the synthesis of intact exotoxin A that expressed ADP-ribosyltransferase activity upon treatment with urea and dithiothreitol.
S T, Chen +4 more
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Analysis of transcription of the exotoxin A gene of Pseudomonas aeruginosa [PDF]
Journal of Bacteriology, 1986 Analysis of RNA isolated from Pseudomonas aeruginosa PA103 and PAKS grown under Fe2+-limiting (0.08 microgram/ml) and Fe2+-sufficient (10 micrograms/ml) conditions demonstrated that exotoxin A (ETA) expression is regulated by Fe2+ at the level of transcription.
C C, Grant, M L, Vasil
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