Results 171 to 180 of about 9,621 (218)

Pseudomonas aeruginosa Exotoxin A

Journal of Burn Care & Rehabilitation, 1992
Bacterial concentrations greater than 10(5) colony-forming units/gm of tissue prevent wound healing. However, it has not been determined whether it is the number of bacteria or a toxin produced by these organisms that impedes the wound healing process.
John P. Heggers, Scott Haydon, Francis Ko, Peter G. Hayward, Martin C. Robson   +4 more
openaire   +1 more source

Crystallization of exotoxin A from Pseudomonas aeruginosa

Journal of Molecular Biology, 1982
Abstract Exotoxin A from Pseudomonas aeruginosa has been crystallized in a form suitable for high resolution diffraction analysis. The crystals, grown in the presence of high concentrations of polyethylene glycol (20%, w/v) and of NaCl (1.5 m ), are monoclinic and contain one monomeric toxin molecule per asymmetric unit. The space group is P 2 1 ,
R J, Collier, D B, McKay
openaire   +2 more sources

Exotoxins of Pseudomonas aeruginosa. II. Concentration, Purification, and Characterization of Exotoxin A

Journal of Infectious Diseases, 1973
Exotoxin A of Pseudomonas aeruginosa (PA-103) could be concentrated readily by precipitation with zinc acetate and ammonium sulfate. The toxin was purified by column chromatography with use of DEAE-cellulose and Sephadex G-200. The final product contained about 8,000 mouse LD,,0/mg of protein.
P V, Liu, S, Yoshii, H, Hsieh
openaire   +2 more sources

Pseudomonas aeruginosaExotoxin A

New England Journal of Medicine, 1980
Pseudomonas aeruginosa is an opportunistic pathogen that causes more than 100,000 infections in the United States each year. Pseudomonas infections are associated with considerable morbidity and mortality despite the use of modern antibiotics.1 Recognition of the limitations of existing therapy for pseudomonas disease has stimulated renewed interest in
openaire   +2 more sources

Regulation of Pseudomonas Aeruginosa Exotoxin a Synthesis

2004
Exotoxin A (ETA) is one of the most toxic virulence factors produced by Pseudomonas aeruginosa 72: Both clinical and experimental animal studies indicate clearly the importance of ETA in the pathogenesis of different P. aeruginosa infections. Most P. aeruginosa clinical isolates produce ETA9, 23, 47.
Abdul N. Hamood, Jane A. Colmer-Hamood, Nancy L. Carty   +2 more
openaire   +1 more source

Effect of Pseudomonas aeruginosa Exotoxin A on Inner Ear Function

Acta Oto-Laryngologica, 1997
Electrophysiological changes were studied in the albino rat following instillation of Pseudomonas aeruginosa exotoxin A into the middle ear cavity through the tympanic membrane. Hearing threshold was measured by a burst-elicited, frequency-specific auditory brainstem response (ABR) technique prior to exposure, then 24 and 48 h, 5 days, 2 and 4 weeks ...
M, Stenqvist, M, Anniko, A, Pettersson
openaire   +2 more sources

Toxoid from Exotoxin A of Pseudomonas aeruginosa: Preparation and Characterization

Journal of Infectious Diseases, 1982
Toxoid was prepared by treating exotoxin A of Pseudomonas aeruginosa with formalin. Coincubation of exotoxin A for two to four weeks at 37 degrees C with 0.5% formalin and 10(-3) M lysine followed by one to two weeks of storage in the absence of these reagents reduced cytotoxicity, preserved antigenicity, and minimized subsequent reversion of the ...
M, Pollack, R K, Prescott
openaire   +2 more sources

Exotoxins of Pseudomonas aeruginosa. III. Characteristics of Antitoxin A

Journal of Infectious Diseases, 1973
Antitoxic sera were produced in rabbits, goats, and ponies with purified exotoxin A of Pseudomonas aeruginosa (strain PA-103). None of these sera contained agglutinating antibody against the bacterial cells, and all antitoxins appeared in the IgG fraction.
P. V. Liu, H. Hsieh
openaire   +1 more source

Pseudomonas aeruginosa exotoxin A

1997
Abstract Pseudomonas aeruginosa exotoxin A (PEA, MW 66 kDa, 613 amino acids, sequence accession number: PSEETA K01397) consists of three major domains (Allured et al. 1986), as indicated in Fig. 1. The N-terminal domain la (amino acids 1-252) binds to the ai-macroglobulin receptor at the cell surface (Kounnas et al.
openaire   +1 more source

Middle ear mucosa changes following exposure to Pseudomonas aeruginosa exotoxin A

European Archives of Oto-Rhino-Laryngology, 1999
Pseudomonas aeruginosa exotoxin A (1 microgram/20 microliters) was instilled into the middle ear cavity in the rat. Morphological changes of the mucosa were analyzed after various intervals using light (LM) and transmission electron microscopy (TEM).
M, Stenqvist, M, Anniko, H, Rask-Andersen   +2 more
openaire   +2 more sources