Results 181 to 190 of about 9,621 (218)

Mapping the enzymatic active site of Pseudomonas aeruginosa exotoxin A

Proteins: Structure, Function, and Bioinformatics, 1988
AbstractPseudomonas aeruginosa exotoxin A is representative of a class of enzymes, the monoADP‐ribosyl, which catalyze the covalent transfer of an ADP‐ribose moiety of NAD+ to a target substrate. Availability of the three‐dimensional structure of exotoxin A provides the opportunity for mapping substrate binding sites and suggesting which amino acid ...
B J, Brandhuber, V S, Allured, T G, Falbel, D B, McKay   +3 more
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Chemical Modification of Pseudomonas aeruginosa Exotoxin A

1978
The author would like to thank Dr. Stephen H. Leppla for his suggestions during the course of the work described in this thesis, and for the independence assigned the author throughout the past three years under his employment. The author thanks Ms. Rebecca B. Dorland for her assistance with the binding assay, for her typing of this thesis, and for her
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Preparation of Recombinant Atoxic Form of Exotoxin A from Pseudomonas Aeruginosa

Bulletin of Experimental Biology and Medicine, 2013
Nucleotide sequences encoding full-length protein of Pseudomonas aeruginosa exotoxin A and its atoxic form were cloned and expressed in Escherichia coli cells. Purified recombinant exotoxin and immune rabbit sera protected mice from exotoxin A.
A A, Kaloshin, M A, Isakov, N A, Mikhailova, Ju V, Vertiev   +3 more
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Anti-ETA IgG Neutralizes the Effects of Pseudomonas aeruginosa Exotoxin A

Journal of Surgical Research, 2002
The opportunistic pathogen Pseudomonas aeruginosa causes severe infections in immunocompromised hosts. Among P. aeruginosa-infected burn patients, mortality may reach as high as 50%. Due to their immunocompromised status, burn patients may benefit from passive immunotherapy against infection.
Matthew R, Fogle, John A, Griswold, Jeffrey W, Oliver, Abdul N, Hamood   +3 more
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Otoprotectant Minimizes Hearing Defects Caused byPseudomonas aeruginosaExotoxin A

Acta Oto-Laryngologica, 2000
Exotoxin A, produced by Pseudomonas aeruginosa (PaExoA), penetrates from the middle ear in to the cochlea and causes sensorineural hearing loss (SNHL). In this investigation we studied electrophysiological changes in the albino rat following instillation of PaExoA and N(G)-nitro-L-arginine methyl ester (L-NAME), a known inhibitor of nitric oxide ...
R, Popa, M, Anniko, M, Takumida
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Expression of Enzymic Activity by Exotoxin A from Pseudomonas aeruginosa

Infection and Immunity, 1980
Exotoxin A from Pseudomonas aeruginosa is a single polypeptide chain ( M r , 66,000) containing little if any adenosine 5′-diphosphate ribosyltransferase or oxidized nicotinamide adenine dinucleotide glycohydrolase activity.
S, Lory, R J, Collier
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Immunosuppressive effects of Pseudomonas aeruginosa exotoxin A on human B-lymphocytes

Toxicon, 1993
In this study we investigated the effects of exotoxin A on proliferation and differentiation of human B-cells in vitro. Exotoxin A at a concentration of 1 microgram/ml inhibited the proliferation of B-cells preactivated by insolubilized anti-IgM antibody or by formalinized Staphylococcus aureus particles, plus IL-2 or IL-4. B-cell blasts obtained after
D R, Vidal, P, Garrone, J, Banchereau
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Diphtheria Toxin and Exotoxin A from Pseudomonas aeruginosa

1979
A marked resurgence of interest in bacterial protein toxins has occurred in recent years, after a long period of relative neglect. Many of the classical toxins have been studied in greater depth, and new toxins have been discovered as well. As a result of the expanded interest and efforts there now exists a substantial and rapidly growing body of ...
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Pseudomonas aeruginosa Exotoxin A

2020
G J, Chaudry, P L, Holmans, R C, Clowes, R K, Draper   +3 more
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Structure—activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A

1988
Although there is no reason in principle why any of several cytocidal bacterial toxins might be used for immuntoxin construction, only two such toxins have been employed extensively to date for this purpose, namely, diphtheria toxin (DT) and Pseudomonas aeruginosa exotoxin A (PE).
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