Results 61 to 70 of about 5,165 (174)

Necrotizing Pneumonia Caused by PVL‐Negative Methicillin‐Susceptible Staphylococcus aureus Complicated by Refractory Pneumothorax: A Case Report

Respirology Case Reports, Volume 14, Issue 1, January 2026.
Here we report a case of PVL‐negative MSSA necrotizing pneumonia in a previously healthy man that rapidly progressed to cavitary lesions and refractory pneumothorax. Despite its improvement after clindamycin‐based therapy, the patient experienced recurrent pneumothorax and chronic respiratory failure.
Shun Endo, Tomoka Yasuda, Makoto Izumi, Kazuhiro Shimaya, Yoshikazu Tsukada   +4 more
wiley   +1 more source

Therapeutic efficacy of Cintredekin Besudotox (IL13-PE38QQR) in murine lung fibrosis is unaffected by immunity to Pseudomonas aeruginosa exotoxin A.

PLoS ONE, 2010
BackgroundWe have previously explored a therapeutic strategy for specifically targeting the profibrotic activity of IL-13 during experimental pulmonary fibrosis using a fusion protein comprised of human IL-13 and a mutated form of Pseudomonas aeruginosa ...
Rogério S Rosada, Ana P Moreira, Fabiani G Frantz, Raj K Puri, Aquilur Rahman, Theodore J Standiford, Carlos R Zárate-Bladés, Célio L Silva, Cory M Hogaboam   +8 more
doaj   +1 more source

Metagenomic and Phenotypic Insights Into Biofilm‐Forming Pathogens in Patients With Nosocomial Sepsis

BioMed Research International, Volume 2026, Issue 1, 2026.
Biofilm‐related infections significantly contribute to bacterial diseases, with estimates suggesting that at least 80% of such infections are associated with biofilms. These infections often involve opportunistic pathogens, which not only influence the type of infection but also impact the microenvironment by interacting with other polymicrobial ...
Haleema Sadia, Arshia Amin, Iftikhar Ahmed, Baisakhi Banerjee   +3 more
wiley   +1 more source

Large-scale purification and characterization of the exotoxin of Pseudomonas aeruginosa [PDF]

Infection and Immunity, 1976
The exotoxin (PE) of Pseudomonas aeruginosa was purified from 50-liter cultures by a simple three-step procedure, yielding 135 mg of essentially homogeneous protein. In Ouchterlony gel diffusion, PE produces a single line which does not interact with a diphtheria toxin-antitoxin precipitin line.
openaire   +2 more sources

Molecular Detection of Virulence Genes among Pseudomonas aeruginosa Strains Isolated from Clinical Specimens by Multiplex PCR

پزشکی بالینی ابن سینا, 2018
Background and Objective: Pseudomonas aeroginosa is the most common pathogen associated with nosocomial infections and possesses virulence factors which contribute to the bacterial invasion and toxicity such as alginate, exoenzyme S, exotoxin A and ...
Afsoon Shariat, Sajad Alizadeh, Mehdi Jahangiri Hoseinabadi, Mohammad Movagharnejad   +3 more
doaj  

Action Mechanism of Essential Oils or Their Components Against Pathogenic Bacteria: Literature Review

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Essential oils (EOs), derived from medicinal and aromatic plants, are natural mixtures of volatile, oily compounds with varying compositions and antibacterial mechanisms. Understanding the mechanisms of EOs and their components (EOCs) is essential for predicting their impacts on various microbes and their interactions with antibiotics.
Mohamed A. El-Sakhawy, Abd El Raheim Mohammed Donia, Tawfiq N. Juraybi, Abeer Ali El-Sherbiny Ateya, Wadah Osman, Amr A. Abd-Elghany, Mohamed Mostafa Soliman, Abdel Naser A. Kobisi, Mohamed A. Balah, Shweta Negi   +9 more
wiley   +1 more source

Cloning and expression of the immunogenic moiety of Pseudomonas aeruginosa exotoxin A

Biological Journal of Microorganism, 2013
Introduction: Pseudomonas aeruginosa, as an opportunistic microorganism, is a major cause of nosocomial infections worldwide. Exotoxin A (ETA) is an extracellular enzyme that is produced by most clinical strains of P. aeruginosa.
Sahar Nouri Gharajelar *, Malahat Ahmadi, Bahman Hosseini   +2 more
doaj  

Phenotypic and Genotypic Profile of Enterobacteriaceae Isolated at a Teaching Hospital in Ghana

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study identified a significant prevalence of antimicrobial resistance determinants within Enterobacteriaceae isolates, with particular emphasis on those producing extended‐spectrum β‐lactamases (ESBL). These isolates harbored diverse antibiotic resistance genes (ARGs), plasmid replicons, and virulence factors (VFs), highlighting the imperative for
Bismark Donkor, Richael Odarkor Mills, Philimon Mwintige, Alberta Bedford Moses, Abigail Asmah Brown, Faustina Halm‐Lai, Oheneba Charles Kofi Hagan   +6 more
wiley   +1 more source

Dissecting HOCl Action in Chronic Wound Biofilms: Proteomic Insights From a Host‐Relevant Model of Pseudomonas aeruginosa

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Impact statement: We tested a gel containing a pure, stable form of hypochlorous acid (HOCl) against P. aeruginosa. To ensure our results reflect the true effects of HOCl we used a host‐relevant biofilm model. The HOCl gel disrupted bacterial metabolism, impacted proteins associated with virulence, and changed the abundance antibiotic resistance ...
Lori I. Robins, Philip Gafken, Chenwei Lin, Lisa Jones, Sarah E. Hooper   +4 more
wiley   +1 more source

Protective effect of DNA vaccine encoding pseudomonas exotoxin A and PcrV against acute pulmonary P. aeruginosa Infection.

PLoS ONE, 2014
Infections with Pseudomonas aeruginosa have been a long-standing challenge for clinical therapy because of complex pathogenesis and resistance to antibiotics, thus attaching importance to explore effective vaccines for prevention and treatment.
Mingzi Jiang, Jing Yao, Ganzhu Feng
doaj   +1 more source