The Brief Case: Pneumonia in a <i>Boa constrictor occidentalis</i> with inclusion body disease caused by multidrug-resistant VIM-type metallo-β-lactamase producing <i>Pseudomonas aeruginosa</i>. [PDF]
Broering Ferreira A +8 more
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Landscape of resistance to ceftolozane/tazobactam and ceftazidime/avibactam in strains of Pseudomonas aeruginosa: a genomic approach in strains without selection pressure in a tertiary-care paediatric hospital in Mexico. [PDF]
A Méndez HE +8 more
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Characterization of Exotoxin of Pseudomonas aeruginosa
Journal of Infectious Diseases, 1974Abstract : Heat-labile exotoxin of Pseudomonas aeruginosa has been purified and concentrated. Studies in mice have shown that the toxin affects protein synthesis in the liver within 3 hr of administration, whereas inhibition of protein synthesis in other organs occurs only during terminal stages.
O R, Pavlovskis +2 more
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Pseudomonas exotoxin — Immunotoxins
1988Monoclonal antibodies can be coupled with PE to make very potent ITs. Two of these ITs (PE-HB21 and OVB-3-PE) have been shown to have antitumor activity in a nude mouse model of ovarian cancer. PE ITs are at least 10-fold more active than the corresponding RTA IT.
D J, FitzGerald +2 more
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Pseudomonas aeruginosa Exotoxin A
Journal of Burn Care & Rehabilitation, 1992Bacterial concentrations greater than 10(5) colony-forming units/gm of tissue prevent wound healing. However, it has not been determined whether it is the number of bacteria or a toxin produced by these organisms that impedes the wound healing process.
John P. Heggers +4 more
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Exotoxin A of Pseudomonas aeruginosa (PA-103) could be concentrated readily by precipitation with zinc acetate and ammonium sulfate. The toxin was purified by column chromatography with use of DEAE-cellulose and Sephadex G-200. The final product contained about 8,000 mouse LD,,0/mg of protein.
P V, Liu, S, Yoshii, H, Hsieh
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Crystallization of exotoxin A from Pseudomonas aeruginosa
Journal of Molecular Biology, 1982Abstract Exotoxin A from Pseudomonas aeruginosa has been crystallized in a form suitable for high resolution diffraction analysis. The crystals, grown in the presence of high concentrations of polyethylene glycol (20%, w/v) and of NaCl (1.5 m ), are monoclinic and contain one monomeric toxin molecule per asymmetric unit. The space group is P 2 1 ,
R J, Collier, D B, McKay
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Pseudomonas aeruginosaExotoxin A
New England Journal of Medicine, 1980Pseudomonas aeruginosa is an opportunistic pathogen that causes more than 100,000 infections in the United States each year. Pseudomonas infections are associated with considerable morbidity and mortality despite the use of modern antibiotics.1 Recognition of the limitations of existing therapy for pseudomonas disease has stimulated renewed interest in
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The production of convulsions by an exotoxin from Pseudomonas tabaci
Toxicology and Applied Pharmacology, 1969Abstract The phytopathogenic bacterium, Pseudomonas tabaci , produces, in culture, an exotoxin which, when purified, causes seizures in mice and rats. The syndrome is similar to that produced by methionine sulfoximine (L-MSO). However, the toxin is at least 10-fold or more potent than is L-MSO.
C, Lamar +3 more
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Pseudomonas aeruginosa Exotoxin: Effect on Cell Cultures
Journal of Infectious Diseases, 1972Abstract : An exotoxin, toxic to both mice and cultured cells, was isolated from cultures of Pseudomonas aeruginosa. Relatively small amounts of the exotoxin inhibited the uptake of uridine and amino acids by Vero cells. Within limits, this toxic action was reversible and could be inactivated by heating at 70 C or by proteolytic digestion, but it was ...
O R, Pavlovskis, F B, Gordon
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