The local cell curvature guides pseudopodia towards chemoattractants [PDF]
HFSP Journal, 2009 Many eukaryotic cells use pseudopodia for movement towards chemoattractants. We developed a computer algorithm to identify pseudopodia, and analyzed how pseudopodia of Dictyostelium cells are guided toward cAMP. Surprisingly, the direction of a pseudopod is not actively oriented toward the gradient, but is always perpendicular to the local cell ...
Peter J.M. Van Haastert +1 more
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Pseudopodia‐like cytoplasmic projections in melanoma cells [PDF]
Diagnostic Cytopathology, 2002 Vishakha Sovani, Anita Borges
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Translocation or just location? Pseudopodia affect fluorescent signals [PDF]
Journal of Cell Biology, 2009 The use of fluorescent probes is one of the most powerful techniques for gaining spatial and temporal knowledge of dynamic events within living cells. Localized increases in the signal from cytosolic fluorescent protein constructs, for example, are frequently used as evidence for translocation of proteins to specific sites within the cell.
Sharon Dewitt +2 more
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Short-hairpin RNA-mediated suppression of cortactin may inhibit the migration and invasion abilities of endometrial cancer cells by reducing lamellipodia [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): The prognosis of endometrial cancer (EC) is significantly affected by tumor infiltration and metastasis. Cortactin (CTTN) regulates infiltration and metastasis in other tumors. Studies on the role and mechanism of CTTN in EC are limited and
Huisi Lin +4 more
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ERK and RhoA Differentially Regulate Pseudopodia Growth and Retraction during Chemotaxis [PDF]
Journal of Biological Chemistry, 2003 Nonmotile cells extend and retract pseudopodia-like structures in a random manner, whereas motile cells establish a single dominant pseudopodium in the direction of movement. This is a critical step necessary for cell migration and occurs prior to cell body translocation, yet little is known about how this process is regulated. Here we show that myosin
Anar A. Brahmbhatt, Richard Klemke
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Uncovering hidden structures: previously undescribed pseudopodia and ectoplasmic structures in planktonic foraminifera [PDF]
Journal of Plankton Research, 2023 Abstract The trophic strategies of cold-water planktonic foraminifera are not well understood due to the challenge of culturing them in polar conditions. Here, we identify previously unknown ectoplasmic and cytoplasmic projections in three species of planktonic foraminifera thriving in polar and subpolar marine environments: Globigerina ...
Mattia Greco +4 more
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Extracellular Signalling Modulates Scar/WAVE Complex Activity through Abi Phosphorylation
Cells, 2021 The lamellipodia and pseudopodia of migrating cells are produced and maintained by the Scar/WAVE complex. Thus, actin-based cell migration is largely controlled through regulation of Scar/WAVE.
Shashi Prakash Singh +2 more
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eIF3a Regulates Colorectal Cancer Metastasis via Translational Activation of RhoA and Cdc42
Frontiers in Cell and Developmental Biology, 2022 Tumor metastasis is the major cause of tumor relapse and cancer-associated mortality in colorectal cancer, leading to poor therapeutic responses and reduced survival. eIF3a was previously described as an oncogene.
Chao Mei +13 more
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A model for a correlated random walk based on the ordered extension of pseudopodia. [PDF]
PLoS Computational Biology, 2010 Cell migration in the absence of external cues is well described by a correlated random walk. Most single cells move by extending protrusions called pseudopodia.
Peter J M Van Haastert
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