Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families. [PDF]
FEBS Open BioIqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Filić V +3 more
europepmc +2 more sources
The ordered extension of pseudopodia by amoeboid cells in the absence of external cues. [PDF]
PLoS ONE, 2009 Eukaryotic cells extend pseudopodia for movement. In the absence of external cues, cells move in random directions, but with a strong element of persistence that keeps them moving in the same direction Persistence allows cells to disperse over larger ...
Leonard Bosgraaf, Peter J M Van Haastert
doaj +1 more source
Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen [PDF]
Microcirculation, 2008 ABSTRACTObjective: Endothelial cells have the ability to undergo morphological shape changes, including projection of cytoplasmic pseudopodia into the capillary lumen. These cytoplasmic projections significantly influence the hemodynamic resistance to blood flow.
Isgard S. Hueck +3 more
openalex +3 more sources
Food searching strategy of amoeboid cells by starvation induced run length extension. [PDF]
PLoS ONE, 2009 Food searching strategies of animals are key to their success in heterogeneous environments. The optimal search strategy may include specialized random walks such as Levy walks with heavy power-law tail distributions, or persistent walks with preferred ...
Peter J M Van Haastert, Leonard Bosgraaf
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Cell polarity and cell migration both depend on pseudopodia and lamellipodia formation. These are regulated by coordinated signaling acting through G-protein coupled receptors and kinases such as PKB/AKT and SGK, as well as the actin cytoskeletal ...
Shashi Prakash Singh +5 more
doaj +1 more source
AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma. [PDF]
, 2012 AHNAK/Desmoyokin is a giant protein which has been recently linked to reorganization of the actin cytoskeleton, cellular migration and invasion. Here, we investigated the role of AHNAK in the pathophysiology of larynx carcinoma-one of the major subtypes ...
Bankfalvi, Agnes +5 more
core +11 more sources
Immature stages of some eastern Nearctic Tabanidae (Diptera). IX. Chrysops beameri Brennan and Hybomitra trispila (Wiedemann) [PDF]
, 2013 The larvae and pupae of two species of Tabanidae (Diptera), Chrysops beameri Brennan and Hybomitra trispila (Wiedemann), are described and illustrated, and their similarities and differences relative to similar species are discussed.
Goodwin, James. T.
core +2 more sources
A Supramolecular Nanoscavengers: Based "Cargo-Exchange" Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy. [PDF]
Adv Sci (Weinh)Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Tian Z +7 more
europepmc +2 more sources
Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodies [PDF]
Laboratory Investigation, 2005 Malignant gliomas (astrocytomas) are lethal tumors that invade the brain. Invasive cell migration is initiated by extension of pseudopodia into interstitial spaces. In this study, U87 glioma cells formed pseudopodia in vitro as cells pushed through 3 microm pores of polycarbonate membranes.
Marie E. Beckner +4 more
openalex +4 more sources
Reactive Oxygen Species as Signaling Molecules in Neutrophil Chemotaxis [PDF]
, 2014 Neutrophil chemotaxis is a critical component in innate immunity. Recently, using a small-molecule functional screening, we identified NADPH-oxidase-dependent Reactive Oxygen Species (ROS) as key regulators of neutrophil chemotactic migration ...
Hattori, Hidenori +3 more
core +1 more source