Results 71 to 80 of about 18,750 (209)

Novel Duck Orthoreovirus Induces Ferroptosis in HD11 Cells by Hijacking Cellular Iron Metabolism and Promoting Iron Accumulation

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Novel duck orthoreovirus (NDRV) infection induces severe splenic necrosis in ducks, resulting in a cascade of detrimental consequences, including immunosuppression, secondary infections, and diminished vaccine efficacy. Avian orthoreovirus (ARV) exhibits high tropism for macrophages, with splenic macrophages being identified as the primary target cells
Hongzhi Wang, Di Lei, Chenchen Jiang, Boyi Xu, Yi Tang, Rendong Fang, Zongfu Wu   +6 more
wiley   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science, Volume 12, Issue 45, December 4, 2025.
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
wiley   +1 more source

Cholesterol Dependence of Pseudorabies Herpesvirus Entry [PDF]

Current Microbiology, 2010
Lipid rafts are special microdomains in the plasma membrane. They are enriched in sphingolipids and cholesterol, playing critical roles in many biological processes. The purpose of this study is to analyze the requirement of cholesterol, a crucial component of lipid rafts for cell infection by pseudorabies virus (PrV). Cholesterol of plasma membrane or
Ren, Xiaofeng, Yin, Jiechao, Li, Guangxing, Herrler, Georg   +3 more
openaire   +2 more sources

Engineered Low‐Endotoxin Bacterial Biomimetic Vesicles for Enhanced Oral Dual‐Antigen Subunit Vaccine Delivery

Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
A genetically engineered low‐endotoxin Salmonella choleraesuis biomimetic vesicle (CSS‐BBV), coated with COS, is utilized to enhance the oral delivery efficacy of subunit vaccines. The modular SpyCatcher/SpG design enables rapid dual‐antigen conjugation, providing a versatile platform for the development of infectious disease vaccines. ABSTRACT Subunit
Xuegang Shen, Shujie Wang, Kunying Qiu, Zeqing Liu, Xiaoxiao Tian, Fandan Meng, Yan‐Dong Tang, Haiwei Wang, Mingxia Sun, Xue‐Hui Cai, Tong‐Qing An, Yong‐Bo Yang   +11 more
wiley   +1 more source

Risk of infection of dairy cattle in the EU with highly pathogenic avian influenza virus affecting dairy cows in the United States of America (H5N1, Eurasian lineage goose/Guangdong clade 2.3.4.4b. genotype B3.13)

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract This opinion assesses the risk of avian influenza H5N1 B3.13 genotype virus infection in EU dairy cattle. Introduction of the virus into EU dairy cattle, poultry or wild birds via trade or migratory birds from the US is assessed as highly unlikely.
EFSA Panel on Animal Health and Welfare (AHAW), Julio Alvarez, Anette Ella Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Alessio Bortolami, Mariette Ducatez, Claire Guinat, El‐Sayed M. Abdelwhab, Laurent Guillier, Maarten Nauta, Photis Papademas, Elisabetta Suffredini, Winy Messens, Alessandro Broglia, Helene Jensen, Kamela Kryemadhi, Andrea Gervelmeyer   +30 more
wiley   +1 more source

Porcine NK cells stimulate proliferation of pseudorabies virus-experienced CD8+ and CD4+ CD8+ T cells [PDF]

, 2018
Natural killer (NK) cells belong to the innate immune system and play a central role in the defense against viral infections and cancer development, but also contribute to shaping adaptive immune responses.
De Pelsmaeker, Steffi, De Regge, Nick, Devriendt, Bert, Favoreel, Herman   +3 more
core   +4 more sources

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

Distribution and Disease Prevalence of Feral Hogs in Missouri

Human-Wildlife Interactions, 2017
No attempts have been made to document the distribution of feral hogs (Sus scrofa) in Missouri. Also, antibody prevalence for pseudorabies virus and swine brucellosis have not been reported from Missouri.
R. Edwin Hartin, Mark R. Ryan, Tyler A. Campbell   +2 more
doaj   +1 more source

Genome-wide gene expression analysis of anguillid herpesvirus 1 [PDF]

, 2013
<p>Background: Whereas temporal gene expression in mammalian herpesviruses has been studied extensively, little is known about gene expression in fish herpesviruses.
Davison, A.J., Engelsma, M.Y., Peeters, B.P.H., Rottier, P.J.M., van Beurden, S.J.   +4 more
core   +3 more sources